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Repatha Side Effects

Generic Name: evolocumab

Note: This page contains side effects data for the generic drug evolocumab. It is possible that some of the dosage forms included below may not apply to the brand name Repatha.

For the Consumer

Applies to evolocumab: subcutaneous solution

As well as its needed effects, evolocumab (the active ingredient contained in Repatha) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking evolocumab, check with your doctor immediately:

Incidence not known:
  • Difficulty with breathing or swallowing
  • fever
  • hives, itching, or rash
  • nausea
  • reddening of the skin, especially around the ears
  • swelling of the eyes, face, or inside of the nose
  • unusual tiredness or weakness

Minor Side Effects

Some evolocumab side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Back pain
  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • body aches or pain
  • chills
  • cough
  • ear congestion
  • headache
  • loss of voice
  • muscle aches
  • sneezing
  • sore throat
  • stuffy or runny nose
Less common:
  • Abdominal or stomach pain
  • bladder pain
  • bloody or cloudy urine
  • blurred vision
  • diarrhea
  • difficult, burning, or painful urination
  • difficulty with moving
  • dizziness
  • frequent urge to urinate
  • loss of appetite
  • lower back or side pain
  • muscle aching or cramping
  • muscle or joint pain
  • muscle stiffness
  • nervousness
  • pain or tenderness around the eyes and cheekbones
  • pounding in the ears
  • slow or fast heartbeat
  • swollen joints

For Healthcare Professionals

Applies to evolocumab: subcutaneous solution

Cardiovascular

Common (1% to 10%): Hypertension[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, gastroenteritis, nausea (1.8%)[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Hypersensitivity

Common (1% to 10%): Hypersensitivity reactions (including rash, eczema, erythema, urticaria)[Ref]

Local

Common (1% to 10%): Injection site reaction (including erythema, pain, bruising)[Ref]

Musculoskeletal

Common (1% to 10%): Back pain, myalgia, musculoskeletal pain, arthralgia (1.8%)[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Neurocognitive events (0.2%)[Ref]

Other

Common (1% to 10%): Influenza, fatigue (1.6%)
Uncommon (0.1% to 1%): Contusion[Ref]

Respiratory

Common (1% to 10%): Influenza, fatigue (1.6%)
Uncommon (0.1% to 1%): Contusion[Ref]

Immunologic

Rare (less than 0.1%): Development anti-drug antibody[Ref]

References

1. "Product Information. Repatha (evolocumab)." Amgen USA, Thousand Oaks, CA.

It is possible that some side effects of Repatha may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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