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Praluent vs Repatha: What's the difference?

Medically reviewed by Melisa Puckey, BPharm. Last updated on Aug 21, 2020.

Praluent compared to Repatha

Official Answer

by Drugs.com

What are the differences between Praluent and Repatha?

The differences between Repatha (evolocumab) and Praluent (alirocumab) are their active ingredients, number of treatment indications, dosage forms available and number of strengths available in syringe and pens forms.

Repatha has more treatment indications than Praluent.

Praluent has two treatment indications compared to Repatha which has three treatment indications, this means Repatha can be used to treat a larger range of people.
The treatment indications Praluent and Repatha both have are:

  • Preventing cardiovascular disease specifically for myocardial infarction, stroke, and unstable angina requiring hospitalization, in adults with established cardiovascular disease.
  • Treating primary hyperlipidemia specifically for adults with primary hyperlipidemia to reduce low-density lipoprotein cholesterol (LDL-C). This includes patients with Heterozygous Familial Hypercholesterolemia [HeFH]). To be used with a change in diet, and can be used with or without other lipid lowering medications.

Repatha has a third treatment indication is:

  • Reduction of LDL-C for patients with Homozygous Familial Hypercholesterolemia (HoFH) to be used with a change in diet, and can be used with or without other lipid lowering therapies eg statins, ezetimibe, LDL apheresis.

Repatha has more dosage forms available than Praluent

Praluent has two dosage forms compared Repatha which has three dosage forms, this may make Repatha more convenient for some patients.
The dosage forms that Praluent and Repatha both have are:

  • single-use prefilled syringe
  • pre-filled pen

Repatha has a third dosage form which is:

  • on-body infusor with prefilled cartridge

Praluent has more strengths available for syringe and pens than Repatha

Repatha has one strength available in syringe and pen compared to Praluent which has two strengths available, this means Praluent patients can have their dose adjusted.
Repatha single-use prefilled syringe and pre-filled pen are available in a strength of

  • 140 mg/mL.

Praluent single-use prefilled syringe and pre-filled pen are available in strengths

  • 75 mg/mL
  • 150mg/mL

What do Repatha and Praluent have in common?

  • Repatha and Praluent are both from the same drug class which is PCSK9
  • Repatha and Praluent should both be used in conjunction with a diet aimed at reducing cholesterol and triglycerides.
  • Repatha and Praluent can be used on their own or in conjunction with lipid-lowering therapies (e.g., statins, ezetimibe). Repatha can also be used in conjunction with LDL apheresis when used for Homozygous Familial Hypercholesterolemia (HoFH).
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