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Pronunciation: AL-i-ROK-ue-mab
Generic name: alirocumab
Brand name: Praluent
Dosage form: Prefilled pen (autoinjector) for subcutaneous use (150 mg/mL; 75 mg/mL)
Drug class: PCSK9 inhibitors

Medically reviewed by Carmen Pope, BPharm. Last updated on Mar 13, 2024.

What is alirocumab?

Alirocumab is an injectable medicine that is given under your skin (subcutaneously) which may be used in adults with: 

Alirocumab may also be used in children aged 8 years and older with HeFH to reduce LDL-C, alongside dietary changes and other LDL-lowering treatments.

Alirocumab works by helping your liver reduce levels of "bad" cholesterol (low-density lipoprotein, or LDL) circulating in your blood. It does this by blocking the effects of the PCSK9 enzyme, which is an enzyme that binds to LDL receptors preventing LDL from being removed from the blood. This results in more receptors being available to remove LDL from the blood, which decreases LDL blood levels.

Alirocumab was first FDA-approved on July 24, 2015.


Hypersensitivity reactions including inflammation of the blood vessels (vasculitis), swelling under the skin (angioedema), and other allergic reactions requiring hospitalization, have been reported with Alirocumab. Discontinue alirocumab and tell your healthcare provider right away if you have an allergic reaction.

It is not known if alirocumab is safe and effective in children who are younger than 8 years of age or in children with other types of high cholesterol (hyperlipidemias). 

Before taking this medicine

You should not use alirocumab if you are allergic to alirocumab, Praulent, or any of the inactive ingredients in the injection.

Pregnancy and breastfeeding

It is not known if alirocumab will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking alirocumab, you are encouraged to call Regeneron at 1-844-734-6643 to share information about the health of you and your baby.

It is not known whether alirocumab passes into breast milk or if it could harm a nursing baby. You should not breastfeed while using it.

How should I use alirocumab?

Use alirocumab exactly as your healthcare provider tells you to use it.

Alirocumab is only part of a complete treatment program that also includes diet, statin medication, and regular blood testing. Follow your doctor's instructions very closely.

Further administration instructions

If your healthcare provider prescribes you the monthly dose, give 2 separate injections in a row, using a different pen for each injection and 2 different injection sites.

Do not stop using Alirocumab without talking with your healthcare provider. If you stop using it, your cholesterol levels can increase.

Alirocumab dosing information

Follow all your healthcare provider's instructions.

Usual Adult Dose for Hyperlipidemia or Heterozygous Familial Hypercholesterolemia

Usual Adult Dose for Heterozygous Familial Hypercholesterolemia (HeFH) undergoing LDL Apheresis

What happens if I miss a dose?

If you forget to use alirocumab or are not able to take the dose at your regular time, inject your missed dose as soon as you remember, within 7 days.

If you missed a dose by more than 7 days and you inject every 2 weeks wait until your next scheduled dose to restart alirocumab or if you inject every 4 weeks start a new schedule from the time you remember to take your dose.

What happens if I overdose?

What happens if I miss a dose?

Give an injection within 7 days after the missed dose. Then give the next injection 2 to 4 weeks after the missed dose was due, to put you back on your regular injection schedule.

If you are more than 7 days late for an injection:

Do not use two doses at one time.

What happens if I overdose?

If you use more alirocumab than you should, talk to your healthcare provider or pharmacist or call the Poison Help line at 1-800-222-1222.

What should I avoid while using alirocumab?

Do not inject alirocumab into skin that is sunburned, infected, swollen, or otherwise irritated.

Alirocumab side effects

Alirocumab can cause serious side effects, including:

Common side effects of alirocumab affecting more than 5% of patients include:

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of alirocumab. Ask your healthcare provider or pharmacist for more information.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect alirocumab?

Other drugs may interact with alirocumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.


Store unused pens in the refrigerator between 36°F to 46°F (2°C to 8°C) in the original carton to protect from light.

Allow to warm to room temperature for 30 to 40 minutes before use.

Keep alirocumab and all medicines out of the reach of children. 


Active ingredients: alirocumab.

Inactive ingredients: histidine, polysorbate 20, sucrose, and Water for Injection, USP. 


Regeneron Pharmaceuticals, Inc.

Popular FAQ

The differences between Repatha (evolocumab) and Praluent (alirocumab) are their active ingredients, number of treatment indications, dosage forms available and number of strengths available in syringe and pens forms. Continue reading

Praluent works by inactivating a protein in the liver called proprotein convertase subtilisin kexin 9 (PCSK9). When Praluent inactivates PCSK9, more receptors are available to capture LDL (“bad”) cholesterol for removal from the blood. Lowering LDL in the blood can help to reduce the incidence of heart disease. Continue reading

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.