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Alirocumab Dosage

Applies to the following strength(s): 75 mg/mL ; 150 mg/mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Homozygous Familial Hypercholesterolemia

Initial dose: 75 mg subcutaneously every 2 weeks
Maximum dose: 150 mg subcutaneously every 2 weeks, if the LDL-C response to initial dose is inadequate

Comments: Measure LDL-C levels within 4 to 8 weeks of initiation or titration to assess response; adjust the dose, if needed.

Uses: Adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease, who require additional lowering of LDL-C

Usual Adult Dose for Cardiovascular Risk Reduction

Initial dose: 75 mg subcutaneously every 2 weeks
Maximum dose: 150 mg subcutaneously every 2 weeks, if the LDL-C response to initial dose is inadequate

Comments: Measure LDL-C levels within 4 to 8 weeks of initiation or titration to assess response; adjust the dose, if needed.

Uses: Adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease, who require additional lowering of LDL-C

Renal Dose Adjustments

Mild to moderate renal dysfunction: No adjustment recommended.
Severe renal dysfunction: No data available

Liver Dose Adjustments

Mild to moderate hepatic dysfunction: No adjustment recommended.
Severe hepatic dysfunction: No data available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Administer this drug by subcutaneous injection into the thigh, abdomen, or upper arm using a single-dose prefilled pen or single-dose prefilled syringe.
-Rotate the injection site.
-The injection should not be administered into areas of active skin disease or injury such as sunburns, skin rashes, inflammation, or skin infections.
-This drug should not be co-administered with other injectable drugs at the same injection site.

Missed Dose:
-Administer the injection within 7 days from the missed dose and then resume the patient's original schedule.
-If the missed dose is not administered within 7 days, wait until the next dose on the original schedule.

Storage requirements: Store in the refrigerator between 36F to 46F (2C to 8C)

Reconstitution/preparation techniques:
-Allow this drug to warm to room temperature for 30 to 40 minutes prior to use; use this drug as soon as possible after it has warmed up. This drug should not be used if it has been at room temperature [77F (25C)] for 24 hours or longer.
-Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. The solution should not be used if it is discolored or contains visible particulate matter.
-Follow aseptic injection techniques.
-Provide proper training to patients and/or caregivers on the preparation and administration of this drug prior to use. Instruct patients and/or caregivers to read and follow the Instructions for Use each time they use this drug.

Limitations of use:
-The effect of this drug on cardiovascular morbidity and mortality has not been determined.

Monitoring: LDL levels

Patient advice:
-If any signs or symptoms of serious allergic reactions occur, discontinue this drug and seek medical attention.
-Patients and caregivers should read the Patient Information and Instructions For Use (IFU) before starting this drug, and with each refill.

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