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Evkeeza Side Effects

Generic name: evinacumab

Medically reviewed by Drugs.com. Last updated on Jan 3, 2024.

Note: This document provides detailed information about Evkeeza Side Effects associated with evinacumab. Some dosage forms listed on this page may not apply specifically to the brand name Evkeeza.

Applies to evinacumab: intravenous solution.

Common side effects of Evkeeza

Some side effects of evinacumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • chills
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • itching at the injection site
  • joint pain
  • loss of appetite
  • muscle aches, pains, or weakness
  • nausea
  • shivering
  • sore throat
  • stuffy or runny nose
  • sweating
  • trouble sleeping
  • vomiting

Less common

  • body aches or pain
  • constipation
  • ear congestion
  • lack or loss of strength
  • loss of voice
  • pain in the arms or legs
  • sneezing
  • stomach pain

Serious side effects of Evkeeza

Along with its needed effects, evinacumab (the active ingredient contained in Evkeeza) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking evinacumab:

Less common

For healthcare professionals

Applies to evinacumab: intravenous solution.

General

The more frequently reported adverse reactions have included nasopharyngitis, influenza-like illness, dizziness, rhinorrhea, and nausea.[Ref]

Hypersensitivity

Anaphylaxis was reported in 1 patient receiving this drug during clinical trials and led to discontinuation of treatment.

Respiratory

Compared to placebo, upper respiratory tract infection and nasal congestion were reported at a higher incidence; incidence was less than 3% of patients.

Immunologic

Compared to placebo, influenza-like illness was reported at a higher incidence; incidence was less than 3% of patients.

Cardiovascular

During clinical trials, transient decreases in diastolic blood pressure and increases in heart rate occurred but did not require intervention and resolved post infusion.

Nervous system

Gastrointestinal

Compared to placebo, constipation and abdominal pain were reported at a higher incidence; incidence was less than 3% of patients.

Musculoskeletal

Other

Local

Infusion site reactions including infusion site pruritus, pyrexia, muscular weakness, nausea, and nasal congestion were reported in 7% of patients (n=6) receiving this drug compared to 4% (n=2) of placebo patients.

References

1. (2021) "Product Information. Evkeeza (evinacumab)." Regeneron Pharmaceuticals Inc

Frequently asked questions

Further information

Evkeeza side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.