Evkeeza Dosage
Generic name: evinacumab 150mg in 1mL
Dosage form: injection, solution, concentrate
Drug class: Miscellaneous antihyperlipidemic agents
Medically reviewed by Drugs.com. Last updated on Jan 13, 2025.
Recommended Dosage
- The recommended dosage of EVKEEZA is 15 mg/kg administered by intravenous (IV) infusion over 60 minutes once monthly (every 4 weeks).
- If a dosage of EVKEEZA is missed, administer as soon as possible. Thereafter, EVKEEZA should be scheduled monthly from the date of the last dosage.
- Assess LDL-C when clinically appropriate. The LDL-lowering effect of EVKEEZA may be measured as early as 2 weeks after initiation.
Preparation Instructions for Intravenous Infusion
- Calculate the dose (mg), total volume (mL) of EVKEEZA required, and the number of vials required based on the patient's current body weight.
- Visually inspect the solution for cloudiness, discoloration, and particulate matter prior to administration. EVKEEZA is a clear to slightly opalescent, colorless to pale-yellow solution. Do not administer if the solution is cloudy or discolored or contains particulate matter.
- EVKEEZA vials are single-dose containers and do not contain a preservative. Observe aseptic technique when preparing EVKEEZA.
- Do not shake the vial. Withdraw the required volume from the vial(s) of EVKEEZA and transfer into an IV infusion bag containing a maximum volume of 250 mL of 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP. Mix the diluted solution by gentle inversion; do not shake.
- The final concentration of the diluted solution should be between 0.5 mg/mL and 20 mg/mL depending on the patient's current body weight.
- Administer the diluted solution immediately after preparation and discard any unused portion left in the vial.
- If not used immediately, store the diluted solution refrigerated at 2 °C to 8 °C (36 °F to 46 °F) for no more than 24 hours from the time of preparation OR at room temperature up to 25 °C (77 °F) for no more than 6 hours from the time of infusion preparation to the end of the infusion. Do not freeze the diluted solution.
Administration Instructions for Intravenous Infusion
- If refrigerated, allow the diluted solution to come to room temperature prior to administration.
- Administer EVKEEZA diluted solution via IV infusion over 60 minutes through an IV line containing a sterile, in-line or add-on, 0.2-micron to 5-micron filter.
- Do not mix other medications with EVKEEZA or administer other medications concomitantly via the same infusion line.
- The rate of infusion may be slowed, interrupted or discontinued if the patient develops any signs of adverse reactions, including infusion or hypersensitivity reactions.
- EVKEEZA can be administered without regard to the timing of lipoprotein apheresis.
Frequently asked questions
- What is the mechanism of action for Evkeeza (evinacumab-dgnb)?
- Is Evkeeza FDA approved as a high cholesterol treatment?
- Where can I find the Evkeeza FDA package insert?
More about Evkeeza (evinacumab)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Drug images
- Side effects
- During pregnancy
- FDA approval history
- Drug class: miscellaneous antihyperlipidemic agents
- Breastfeeding
- En español
Patient resources
Professional resources
Related treatment guides
See also:
Repatha
Repatha is used to lower high cholesterol alongside dietary changes and to reduce the risk of major ...
Lipitor
Lipitor is used to treat high cholesterol. Learn about side effects, interactions and indications.
Leqvio
Leqvio is used in adults with primary hyperlipidemia to reduce low-density lipoprotein (LDL-C) ...
Crestor
Crestor (rosuvastatin) is used to treat high cholesterol and high triglycerides in the blood ...
Simvastatin
Simvastatin (Zocor) is a cholesterol-lowering medication that blocks the production of cholesterol ...
Ezetimibe
Ezetimibe is used alone or with other medication to treat high cholesterol. Learn about side ...
Rosuvastatin
Rosuvastatin is a prescription medication used to treat high cholesterol and prevent heart disease ...
Atorvastatin
Atorvastatin is a cholesterol-lowering medication that blocks the production of cholesterol. Learn ...
Zetia
Zetia (ezetimibe) is used to treat high cholesterol. Includes Zetia side effects, interactions and ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
