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Zocor Dosage

Generic name: SIMVASTATIN 80mg
Dosage form: tablet, film coated
Drug class: Statins

Medically reviewed by Last updated on Aug 9, 2023.

Important Dosage and Administration Information

  • ZOCOR is no longer marketed in the 5 mg and 80 mg strengths. For dosing with the 5 mg strength, use another simvastatin product.
  • Take ZOCOR orally once daily in the evening.
  • The maximum recommended dosage is ZOCOR 40 mg once daily [see Dosage and Administration (2.2, 2.3)]. An 80 mg daily dosage of ZOCOR is restricted to patients who have been taking simvastatin 80 mg daily chronically (e.g., for 12 months or more) without evidence of muscle toxicity [see Warnings and Precautions (5.1)].
  • If as dose is missed, take the missed dose as soon as possible. Do not double the next dose.
  • For patients that require a high-intensity statin or are unable to achieve their LDL-C goal receiving ZOCOR 40 mg daily, prescribe alternative LDL-C-lowering treatment.
  • Assess LDL-C when clinically appropriate, as early as 4 weeks after initiating ZOCOR, and adjust the dosage if necessary.

Recommended Dosage in Adult Patients

The recommended dosage range of ZOCOR is 20 mg to 40 mg once daily.

Recommended Dosage in Pediatric Patients 10 Years of Age and Older with HeFH

The recommended dosage range of ZOCOR is 10 mg to 40 mg daily.

Recommended Dosage in Patients with Renal Impairment

For patients with severe renal impairment [creatinine clearance (CLcr) 15 – 29 mL/min], the recommended starting dosage of simvastatin is 5 mg once daily [see Warnings and Precautions (5.1) and Use in Specific Populations (8.6)]. Use another simvastatin product to initiate dosing in such patients [see Dosage and Administration (2.1)].

There are no dosage adjustment recommendations for patients with mild or moderate renal impairment.

Dosage Modifications Due to Drug Interactions

Concomitant use of ZOCOR with the following drugs requires dosage modification of ZOCOR [see Warnings and Precautions (5.1) and Drug Interactions (7.1)].

Patients taking Lomitapide

Reduce the dosage of ZOCOR by 50%. Do not exceed ZOCOR 20 mg once daily (or 40 mg once daily for patients who have previously taken an 80 mg daily dosage of ZOCOR chronically while taking lomitapide) [see Dosage and Administration (2.1)].

Patients taking Verapamil, Diltiazem, or Dronedarone

Do not exceed ZOCOR 10 mg once daily.

Patients taking Amiodarone, Amlodipine, or Ranolazine

Do not exceed ZOCOR 20 mg once daily.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.