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Rosuvastatin Side Effects

Medically reviewed by Drugs.com. Last updated on Dec 13, 2021.

Summary

Commonly reported side effects of rosuvastatin include: myalgia. Other side effects include: asthenia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to rosuvastatin: oral capsules, oral tablets

Side effects include:

Headache, nausea, myalgia, asthenia, constipation, abdominal pain.

For Healthcare Professionals

Applies to rosuvastatin: oral capsule, oral tablet

General

The most frequently reported side effects included headache, myalgia, abdominal pain, asthenia, and nausea.[Ref]

Musculoskeletal

Very common (10% or more): Myalgia (up to 12.7%), arthralgia (10.1%)

Rare (less than 0.1%): Myopathy, rhabdomyolysis, myositis

Frequency not reported: Immune-mediated necrotizing myopathy, tendon disorders, creatine phosphokinase increased[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain, nausea, constipation

Rare (less than 0.1%): Pancreatitis

Frequency not reported: Diarrhea[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness

Very rare (less than 0.01%): Polyneuropathy, memory loss

Postmarketing reports: Cognitive impairment, forgetfulness, amnesia, memory impairment, peripheral neuropathy[Ref]

Hepatic

Rare (0.01% to 0.1%): Hepatic transaminases/enzymes increased

Very rare (less than 0.01%): Jaundice, hepatitis

Frequency not reported: Bilirubin increased

Postmarketing reports: Fatal hepatic failure, nonfatal hepatic failure[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash, pruritus, urticaria

Rare (less than 0.1%): Angioedema

Frequency not reported: Stevens-Johnson syndrome[Ref]

Renal

Frequency not reported: Acute renal failure[Ref]

Genitourinary

Very rare (less than 0.01%): Hematuria

Frequency not reported: Proteinuria, myoglobinuria, sexual dysfunction[Ref]

Other

Common (1% to 10%): Asthenia

Frequency not reported: Edema, glutamyl transpeptidase increased, alkaline phosphatase increased[Ref]

Respiratory

Frequency not reported: Cough, dyspnea, interstitial lung disease[Ref]

Psychiatric

Frequency not reported: Confusion, depression, insomnia, nightmares, sleep disorders/disturbances[Ref]

Endocrine

Very rare (less than 0.01%): Gynecomastia

Frequency not reported: Thyroid function abnormalities[Ref]

Metabolic

Common (1% to 10%): Diabetes mellitus

Frequency not reported: Glucose elevated, HbA1c increased[Ref]

Hematologic

Rare (less than 0.1%): Thrombocytopenia[Ref]

Hypersensitivity

Rare (less than 0.1%): Hypersensitivity reaction[Ref]

References

1. "Product Information. Crestor (rosuvastatin)." AstraZeneca Pharma Inc (2003):

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.