Skip to Content

Lescol XL

Generic Name: fluvastatin (FLOO va sta tin)
Brand Name: Lescol, Lescol XL

Medically reviewed by on Sep 27, 2019 – Written by Cerner Multum

What is Lescol XL?

Lescol XL is used together with diet to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).

Lescol XL is used to slow the build-up of plaque (fatty deposits) in your blood vessels.

Lescol XL is also used to lower the risk of heart complications in certain people with coronary heart disease.

Lescol XL is used in adults and children who are at least 10 years old.

Lescol XL may also be used for purposes not listed in this medication guide.

Important Information

You should not take Lescol XL if you have liver disease, or if you are breast-feeding a baby.

Do not use if you are pregnant. If you become pregnant, stop taking Lescol XL and tell your doctor right away.

Some medicines can cause unwanted or dangerous effects when used with Lescol XL. Tell your doctor about all other medicines you use.

Before taking this medicine

You should not take Lescol XL if you are allergic to it, or if:

  • you have active liver disease; or

  • you are pregnant or breast-feeding.

Lescol XL can harm an unborn baby. Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Use effective birth control to prevent pregnancy while you are taking this medicine.

Fluvastatin can pass into breast milk and may cause side effects in the nursing baby. Do not take fluvastatin if you are breast-feeding.

To make sure Lescol XL is safe for you, tell your doctor if you have ever had:

  • liver disease;

  • muscle pain or weakness;

  • kidney disease;

  • diabetes;

  • a thyroid disorder; or

  • if you drink more than 2 alcoholic beverages daily.

Lescol XL can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

Lescol XL is not approved for use by anyone younger than 10 years old.

How should I take Lescol XL?

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take Lescol XL in larger or smaller amounts or for longer than recommended.

Lescol XL is usually taken once or twice daily, with or without food.

Do not crush, chew, break, or open a Lescol XL tablet or capsule. Swallow it whole. Tell your doctor if you have trouble swallowing the pill.

You can take an extended-release tablet at any time of day.

The regular tablet or capsule should be taken at the same time(s) each day. Follow your doctor's dosing instructions very carefully.

Take this medicine with a full glass of water.

While using Lescol XL, you may need frequent blood tests.

It may take up to 4 weeks before your cholesterol levels improve. Keep using this medicine as directed, even if you feel well. High cholesterol usually has no symptoms.

Lescol XL is only part of a complete treatment program that may also include diet, exercise, and weight control. Follow your doctor's instructions very closely.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If you are more than 12 hours late, skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Lescol XL?

Avoid eating foods that are high in fat or cholesterol. Lescol XL will not be as effective in lowering your cholesterol if you do not follow a cholesterol lowering diet plan.

Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.

Lescol XL side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, Lescol XL can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine.

Also call your doctor at once if you have:

  • signs of a kidney problem--little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath; or

  • liver problems--upper stomach pain, loss of appetite, tiredness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Lescol XL?

Some drugs can increase your risk of serious muscle problems if you take them together with Lescol XL. Your doctor may need to change your treatment plan if you use any of the following drugs:

Many other drugs can interact with Lescol XL. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:

  • other cholesterol medications;

  • an antibiotic or antifungal medicine;

  • diabetes medicine;

  • heart medication;

  • seizure medication; or

  • medicine to treat excess stomach acid or stomach ulcer.

This list is not complete and many other drugs can interact with Lescol XL. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Related questions