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Fenofibric acid

Generic Name: fenofibric acid (FEN oh FYE brik AS id)
Brand Name: Fibricor, Trilipix

Medically reviewed on December 7, 2017

What is fenofibric acid?

Fenofibric acid helps reduce cholesterol and triglycerides (fatty acids) in the blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries).

Fenofibric acid is used to treat high cholesterol and high triglyceride levels. It is sometimes given together with other cholesterol-lowering medications.

Fenofibric acid may also be used for purposes not listed in this medication guide.

Important Information

You should not take fenofibric acid if you have liver disease, gallbladder disease, severe kidney disease, or if you are breast-feeding a baby.

In rare cases, fenofibric acid can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine.

Before taking this medicine

You should not take fenofibric acid if you are allergic to it, or if you have:

  • severe kidney disease (or if you are on dialysis);

  • liver disease;

  • gallbladder disease; or

  • if you are breast-feeding a baby.

To make sure fenofibric acid is safe for you, tell your doctor if you have ever had:

  • kidney disease;

  • liver disease;

  • gallbladder problems; or

  • an allergic reaction to any medication.

Fenofibric acid can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breast-feed while you are taking fenofibric acid.

Fenofibric acid is not approved for use by anyone younger than 18 years old.

How should I take fenofibric acid?

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

You may take fenofibric acid with or without food.

Do not crush, chew, break, or dissolve a fenofibric acid capsule or tablet. Swallow it whole.

If you also take cholestyramine, colesevelam, or colestipol, take these other medicines at least 1 hour after or 4 to 6 hours before you take fenofibric acid.

While using fenofibric acid, you may need frequent blood tests. Your gallbladder, kidney function, and liver function may also need to be checked. You may not notice any change in your symptoms, but your blood work will help your doctor determine how long to treat you with fenofibric acid.

Fenofibric acid is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking fenofibric acid?

Avoid eating foods that are high in fat or cholesterol. Fenofibric acid will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.

Fenofibric acid side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

In rare cases, fenofibric acid can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine.

Also call your doctor at once if you have:

  • sharp stomach pain spreading to your back or shoulder blade;

  • loss of appetite, stomach pain just after eating a meal;

  • jaundice (yellowing of the skin or eyes);

  • low blood cell counts--fever, chills, weakness, mouth sores, easy bruising, unusual bleeding;

  • signs of a blood clot in your leg--pain, swelling, warmth, or redness in one or both legs; or

  • signs of a blood clot in your lung--chest pain, sudden cough, wheezing, rapid breathing, coughing up blood.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Fenofibric acid dosing information

Usual Adult Dose for Hypertriglyceridemia:

Capsules:
-Initial dose: 45 to 135 mg orally once a day
-Maximum dose: 135 mg once a day

Tablets:
-Initial dose: 35 to 105 mg orally per day
-Maximum dose: 105 mg once a day

Comments:
-Dosages should be individualized according to patient response and if necessary, adjusted following repeat lipid determinations at 4 to 8 week intervals.

Use: As an adjunct to diet to reduce triglycerides (TG) in patients with severe hypertriglyceridemia (500 mg/dL or greater); elevated TG levels of 2000 mg/dL or higher may increase the risk of developing pancreatitis

Usual Adult Dose for Hyperlipidemia:

Capsules:
135 mg orally once a day

Tablets:
105 mg orally per day

Use: As an adjunct to diet to reduce elevated low-density lipoprotein cholesterol (LDL-C), total cholesterol (Total-C), TG, and apolipoprotein B (Apo B), and to increase high-density lipoprotein cholesterol (HDL-C) in patients with primary hypercholesterolemia or mixed dyslipidemia

Usual Adult Dose for Dyslipidemia:

Capsules:
135 mg orally once a day

Tablets:
105 mg orally per day

Use: As an adjunct to diet to reduce elevated low-density lipoprotein cholesterol (LDL-C), total cholesterol (Total-C), TG, and apolipoprotein B (Apo B), and to increase high-density lipoprotein cholesterol (HDL-C) in patients with primary hypercholesterolemia or mixed dyslipidemia

What other drugs will affect fenofibric acid?

Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete. Other drugs may interact with fenofibric acid, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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