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Lomitapide Side Effects

For the Consumer

Applies to lomitapide: oral capsule

In addition to its needed effects, some unwanted effects may be caused by lomitapide. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking lomitapide:

More common:
  • Arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • dark urine
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • light-colored stools
  • loss of appetite
  • nausea and vomiting
  • sweating
  • trouble breathing
  • unusual tiredness or weakness
  • upper right abdominal or stomach pain
  • yellow eyes and skin

Minor Side Effects

Some of the side effects that can occur with lomitapide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Acid or sour stomach
  • back pain
  • belching
  • chills
  • constipation
  • cough
  • decreased weight
  • diarrhea
  • dizziness
  • excess air or gas in the stomach or intestines
  • frequent urge to defecate
  • full or bloated feeling
  • general feeling of discomfort or illness
  • headache
  • heartburn
  • indigestion
  • joint pain
  • muscle aches and pains
  • passing gas
  • pressure in the stomach
  • shivering
  • sore throat
  • stomach discomfort, upset, or pain
  • straining while passing stool
  • stuffy or runny nose
  • sweating
  • swelling of the abdominal or stomach area
  • trouble sleeping
  • weakness

For Healthcare Professionals

Applies to lomitapide: oral capsule


Very common (10% or more): Chest pain (24%), angina pectoris (10%), palpitations (10%)[Ref]


Very common (10% or more): Diarrhea (79%), nausea (65%), dyspepsia (38%), vomiting (34%), abdominal pain (34%), abdominal discomfort (21%), abdominal distention (21%), constipation (21%), flatulence (21%), gastroesophageal reflux disease (10%), defecation urgency ((10%), rectal tenesmus (10%), gastroenteritis (14%)[Ref]


Very common (10% or more): Increased ALT (17%), at least one elevation in ALT and/or AST greater than or equal to 3 times ULN (29%), hepatic steatosis: of 23 patients in a study for 78 weeks, 18 (78%) exhibited an increase in hepatic fat greater than 5% and 3 (13%) exhibited an increase greater than 20%[Ref]


Very common (10% or more): Influenza (21%)[Ref]


Very common (10% or more): Weight loss (24%)[Ref]

Nervous system

Very common (10% or more): Fatigue (17%), fever (10%), headache (10%), dizziness (10%)[Ref]


Very common (10% or more): Nasopharyngitis (17%), pharyngolaryngeal pain (14%), nasal congestion (10%)[Ref]


Common (1% to 10%): Ecchymosis, papule, rash erythematous, xanthoma[Ref]


1. "Product Information. Juxtapid (lomitapide)." Aegerion Pharmaceuticals Inc, Cambridge, MA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for lomitapide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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