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Lomitapide Side Effects

In Summary

Commonly reported side effects of lomitapide include: increased serum alanine aminotransferase, increased serum aspartate aminotransferase, abdominal distention, abdominal distress, abdominal pain, constipation, diarrhea, dyspepsia, fever, nausea, vomiting, and flatulence. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to lomitapide: oral capsule

Along with its needed effects, lomitapide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lomitapide:

More common
  • Arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • dark urine
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • light-colored stools
  • loss of appetite
  • nausea and vomiting
  • sweating
  • trouble breathing
  • unusual tiredness or weakness
  • upper right abdominal or stomach pain
  • yellow eyes and skin

Some side effects of lomitapide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Acid or sour stomach
  • back pain
  • belching
  • chills
  • constipation
  • cough
  • decreased weight
  • diarrhea
  • dizziness
  • excess air or gas in the stomach or intestines
  • frequent urge to defecate
  • full or bloated feeling
  • general feeling of discomfort or illness
  • headache
  • heartburn
  • indigestion
  • joint pain
  • muscle aches and pains
  • passing gas
  • pressure in the stomach
  • shivering
  • sore throat
  • stomach discomfort, upset, or pain
  • straining while passing stool
  • stuffy or runny nose
  • sweating
  • swelling of the abdominal or stomach area
  • trouble sleeping
  • weakness

For Healthcare Professionals

Applies to lomitapide: oral capsule


Very common (10% or more): Chest pain (24%), angina pectoris (10%), palpitations (10%)[Ref]


Very common (10% or more): Diarrhea (79%), nausea (65%), dyspepsia (38%), vomiting (34%), abdominal pain (34%), abdominal discomfort (21%), abdominal distention (21%), constipation (21%), flatulence (21%), gastroesophageal reflux disease (10%), defecation urgency ((10%), rectal tenesmus (10%), gastroenteritis (14%)[Ref]


Very common (10% or more): Increased ALT (17%), at least one elevation in ALT and/or AST greater than or equal to 3 times ULN (29%), hepatic steatosis: of 23 patients in a study for 78 weeks, 18 (78%) exhibited an increase in hepatic fat greater than 5% and 3 (13%) exhibited an increase greater than 20%[Ref]


Very common (10% or more): Influenza (21%)[Ref]


Very common (10% or more): Weight loss (24%)[Ref]

Nervous system

Very common (10% or more): Fatigue (17%), fever (10%), headache (10%), dizziness (10%)[Ref]


Very common (10% or more): Nasopharyngitis (17%), pharyngolaryngeal pain (14%), nasal congestion (10%)[Ref]


Common (1% to 10%): Ecchymosis, papule, rash erythematous, xanthoma[Ref]


1. "Product Information. Juxtapid (lomitapide)." Aegerion Pharmaceuticals Inc, Cambridge, MA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of lomitapide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.