Crestor Dosage

General Dosage and Administration Information

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Administer CRESTOR orally as a single dose at any time of day, with or without food. Swallow the tablets whole.

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Assess LDL-C when clinically appropriate, as early as 4 weeks after initiating CRESTOR, and adjust the dosage if necessary.

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If a dose is missed, advise patients not to take an extra dose. Resume treatment with the next dose.

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When taking CRESTOR with an aluminum and magnesium hydroxide combination antacid, administer CRESTOR at least 2 hours before the antacid.

Recommended Dosage in Adult Patients

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The dosage range for CRESTOR is 5 to 40 mg orally once daily.

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The recommended dose of CRESTOR depends on a patient’s indication for usage, LDL-C, and individual risk for CV events.

Recommended Dosage in Pediatric Patients

Dosage in Pediatric Patients 8 Years of Age and Older with HeFH

The recommended dosage range is 5 mg to 10 mg orally once daily in patients aged 8 years to less than 10 years and 5 mg to 20 mg orally once daily in patients aged 10-years and older.

Dosage in Pediatric Patients 7 Years of Age and Older with HoFH

The recommended dosage is 20 mg orally once daily.

Dosing in Asian Patients

Initiate CRESTOR at 5 mg once daily due to increased rosuvastatin plasma concentrations. Consider the risks and benefits of CRESTOR when treating Asian patients not adequately controlled at doses up to 20 mg once daily.

Recommended Dosage in Patients with Renal Impairment

In patients with severe renal impairment (CLcr less than 30 mL/min/1.73 m2) not on hemodialysis, the recommended starting dosage is 5 mg once daily and should not exceed 10 mg once daily.

There are no dosage adjustment recommendations for patients with mild and moderate renal impairment.

Dosage Modifications Due to Drug Interactions

Table 1 displays dosage modifications for CRESTOR due to drug interactions.