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Praluent Dosage

Generic name: ALIROCUMAB 75mg in 1mL
Dosage form: injection, solution
Drug class: PCSK9 inhibitors

Medically reviewed by Drugs.com. Last updated on Sep 3, 2024.

Recommended Dosage in Adults

  • Established cardiovascular disease or with primary hyperlipidemia, including HeFH:
    • The recommended starting dosage of PRALUENT is either 75 mg once every 2 weeks or 300 mg once every 4 weeks administered subcutaneously.
    • For patients receiving PRALUENT 300 mg every 4 weeks, measure LDL-C just prior to the next scheduled dose, because LDL-C can vary between doses in some patients.
    • If the LDL-C response is inadequate, the dosage may be adjusted to 150 mg subcutaneously every 2 weeks.
  • HeFH undergoing LDL apheresis or with HoFH:
    • The recommended dosage of PRALUENT is 150 mg once every 2 weeks administered subcutaneously.
    • PRALUENT can be administered without regard to the timing of LDL apheresis.
    • Assess LDL-C when clinically appropriate. The LDL-lowering effect of PRALUENT may be measured as early as 4 weeks after initiation.

Recommended Dosage in Pediatric Patients aged 8 years and older with HeFH

  • The recommended dosage of PRALUENT for patients with a body weight less than 50 kg is 150 mg once every 4 weeks administered subcutaneously.
    • If the LDL-C lowering response is inadequate, the dosage may be adjusted to 75 mg subcutaneously once every 2 weeks.
  • The recommended dosage of PRALUENT for patients with a body weight of 50 kg or more is 300 mg once every 4 weeks administered subcutaneously.
    • If the LDL-C lowering response is inadequate, the dosage may be adjusted to 150 mg subcutaneously once every 2 weeks.
  • Assess LDL-C when clinically appropriate. The LDL-lowering effect of PRALUENT may be measured as early as 4 weeks after initiation.

Missed Doses

If a dose is missed:

  • Within 7 days from the missed dose, instruct the patient to administer PRALUENT and resume the patient's original schedule.
  • More than 7 days after the missed dose:
    • For every 2-week dosage, instruct the patient to wait until the next dose on the original schedule.
    • For every 4-week dosage, instruct the patient to administer the dose and start a new schedule based on this date.

Important Administration Instructions

  • Train patients and/or caregivers on how to prepare and administer PRALUENT, according to the Instructions for Use and instruct them to read and follow the Instructions for Use each time they use PRALUENT.
  • In children aged 12 to 17 years, it is recommended that PRALUENT be given by or under the supervision of an adult. In children aged 8 to 11 years, PRALUENT should be given by a caregiver.
  • Prior to use, allow PRALUENT to warm to room temperature for 30 to 40 minutes if PRALUENT has been refrigerated.
  • Visually inspect PRALUENT prior to administration. PRALUENT is a clear, colorless to pale yellow solution. Do not use if the solution is cloudy, discolored, or contains particles.
  • Administer PRALUENT subcutaneously into areas of the thigh, abdomen, or upper arm that are not tender, bruised, red, or indurated. Rotate injection sites for each administration.
  • To administer the 300 mg dose, give two 150 mg PRALUENT injections consecutively at two different injection sites.

Frequently asked questions

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.