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Medications for Dry Eye Disease (Keratoconjunctivitis Sicca)

Other names: Dry Eye Syndrome; Keratitis Sicca

A persistent dryness of the cornea and conjunctiva due to decreased function of the tear glands. the cornea may be thickened and visual acuity may be decreased. See also conjunctivitis, tearing, decreased, vitamin a deficiency, and sjogren syndrome.

Drugs used to treat Dry Eye Disease

The following list of medications are in some way related to or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Restasis 4.4 187 reviews
Rx C N

Generic name: cyclosporine ophthalmic

Drug class: ophthalmic anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Xiidra 3.7 266 reviews
Rx N

Generic name: lifitegrast ophthalmic

Drug class: ophthalmic anti-inflammatory agents

For consumers: dosage, side effects

For professionals: Prescribing Information

cyclosporine 4.3 220 reviews
Rx C N

Generic name: cyclosporine ophthalmic

Brand names:  Restasis, Cequa

Drug class: ophthalmic anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Cequa 4.2 20 reviews
Rx C N

Generic name: cyclosporine ophthalmic

Drug class: ophthalmic anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

lifitegrast 3.7 269 reviews
Rx N

Generic name: lifitegrast ophthalmic

Brand name:  Xiidra

Drug class: ophthalmic anti-inflammatory agents

For consumers: dosage, side effects

For professionals: AHFS DI Monograph

Tyrvaya 6.3 3 reviews
Rx C N X

Generic name: varenicline systemic

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

loteprednol 9.7 3 reviews
Rx C N

Generic name: loteprednol ophthalmic

Brand name:  Eysuvis

Drug class: ophthalmic steroids

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Eysuvis 9.7 3 reviews
Rx C N

Generic name: loteprednol ophthalmic

Drug class: ophthalmic steroids

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Systane 1.9 68 reviews
Rx/OTC N N

Generic name: ocular lubricant ophthalmic

Drug class: ophthalmic lubricants and irrigations

For consumers: side effects

Artificial Tears Rate Add review
Rx/OTC N N

Generic name: ocular lubricant ophthalmic

Drug class: ophthalmic lubricants and irrigations

For consumers: side effects

Refresh 10 1 review
Rx/OTC N N

Generic name: ocular lubricant ophthalmic

Drug class: ophthalmic lubricants and irrigations

For consumers: side effects

Systane Ultra 2.0 24 reviews
Rx/OTC N N

Generic name: ocular lubricant ophthalmic

Drug class: ophthalmic lubricants and irrigations

For consumers: side effects

Lacrisert 8.4 12 reviews
Rx/OTC N N

Generic name: ocular lubricant ophthalmic

Drug class: ophthalmic lubricants and irrigations

For consumers: dosage, side effects

For professionals: Prescribing Information

Refresh Tears 1.0 1 review
Rx/OTC N N

Generic name: ocular lubricant ophthalmic

Drug class: ophthalmic lubricants and irrigations

For consumers: side effects

TheraTears Rate Add review
Rx/OTC N N

Generic name: ocular lubricant ophthalmic

Drug class: ophthalmic lubricants and irrigations

For consumers: side effects

varenicline 6.3 3 reviews
Rx C N X

Generic name: varenicline systemic

Brand name:  Tyrvaya

Drug class: smoking cessation agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

FreshKote 5.8 6 reviews
Rx/OTC N N

Generic name: ocular lubricant ophthalmic

Drug class: ophthalmic lubricants and irrigations

For consumers: side effects

GenTeal Rate Add review
Rx/OTC N N

Generic name: ocular lubricant ophthalmic

Drug class: ophthalmic lubricants and irrigations

For consumers: side effects

Systane Balance 2.8 7 reviews
Rx/OTC N N

Generic name: ocular lubricant ophthalmic

Drug class: ophthalmic lubricants and irrigations

For consumers: side effects

Akwa Tears Rate Add review
Rx/OTC N N

Generic name: ocular lubricant ophthalmic

Drug class: ophthalmic lubricants and irrigations

For consumers: side effects

Celluvisc Rate Add review
Rx/OTC N N

Generic name: ocular lubricant ophthalmic

Drug class: ophthalmic lubricants and irrigations

For consumers: side effects

Refresh Celluvisc 4.0 1 review
Rx/OTC N N

Generic name: ocular lubricant ophthalmic

Drug class: ophthalmic lubricants and irrigations

For consumers: side effects

Refresh Liquigel 9.0 1 review
Rx/OTC N N

Generic name: ocular lubricant ophthalmic

Drug class: ophthalmic lubricants and irrigations

For consumers: side effects

Refresh Optive Rate Add review
Rx/OTC N N

Generic name: ocular lubricant ophthalmic

Drug class: ophthalmic lubricants and irrigations

For consumers: side effects

Refresh Optive Advanced Rate Add review
Rx/OTC N N

Generic name: ocular lubricant ophthalmic

Drug class: ophthalmic lubricants and irrigations

For consumers: side effects

Learn more about Dry Eye Disease

Care guides

Symptoms and treatments

Medicine.com guides (external)

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.