Generic name: perfluorohexyloctane
Dosage form: ophthalmic solution
Drug class: Ophthalmic anti-inflammatory agents

Medically reviewed by Judith Stewart, BPharm. Last updated on May 12, 2025.

What is Miebo?

Miebo is a prescription eye drop used to treat the signs and symptoms of dry eye disease.

Miebo works to treat dry eye disease by preventing excessive tear evaporation.

Miebo contains perfluorohexyloctane, a semifluorinated alkane that works to stabilize the tear film on the surface of the eye, stopping the tears from evaporating and preventing drying of the eyes.

It is not known if this medicine is safe and effective in children under the age of 18.

What is Miebo used to treat?

Miebo is used to treat the signs and symptoms of dry eye disease (DED).

Dry eye disease occurs when the eyes don’t make enough tears to stay lubricated, or when the tears don’t work correctly due to an imbalance in the tear lipid layer.

One of the most common causes of dry eye disease is excessive tear evaporation, which can be caused by a dysfunction of the Meibomian glands. Meibomian glands are oil glands along the edge of the eyelids where the eyelashes are found. They produce an oil that is an important part of the tear film, and it is what stops the tears from evaporating too quickly.

When the tears evaporate too quickly, the eyes become dry and inflamed, eventually causing damage to the surface of the eye.

Miebo works to stop dry eyes by preventing excessive evaporation of the tear film.

Who should not use Miebo?

Do not use this medicine if you are allergic to perfluorohexyloctane.

Before using Miebo

Before you start treatment, tell your doctor if you:

• are using any other eye drops
• wear contact lenses.

Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant. There are no data for Miebo use during pregnancy.

Breastfeeding

Tell your doctor if you are breastfeeding or plan to breastfeed. There are no data for Miebo use during breastfeeding. Talk to your doctor about the best way to feed your baby during treatment.

How should I use Miebo?

Use this medicine exactly as prescribed.

The recommended dosage is one drop to be instilled into each eye four times daily.

Remove contact lenses before using the drops and wait for at least 30 minutes before reinserting.

Administration Instructions

Step 1. Remove the cap from eye drop bottle.

Step 2. Holding the bottle upright, gently squeeze the bottle.

Step 3. While squeezing, turn the bottle upside down and release the pressure (drawing air into the bottle).

Step 4. Keeping the bottle upside down, place the bottle above your eye and squeeze it again to release a drop into your eye.

Repeat steps 1 - 4 for the second affected eye.

Dosing information

Usual Adult Dose for Dry Eye Disease:

- one drop into each eye four times daily.

Use: treatment of the signs and symptoms of dry eye disease.

Miebo side effects

Common side effects include:

• blurred vision
• eye redness.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Related/similar drugs

How should I store Miebo?

• Store Miebo ophthalmic solution at 15ºC to 25ºC (59ºF to 77ºF).
• After opening, the ophthalmic solution can be used until the expiration date on the bottle.

Keep all medicines out of the reach of children and pets.

General information about the safe and effective use of Miebo

Medicines are sometimes prescribed for purposes other than those listed in a medication guide. You can ask your pharmacist or doctor for information that is written for health professionals. Do not use this medicine for a condition for which it was not prescribed. Do not give it to other people, even if they have the same symptoms you have. It may harm them.

What are the ingredients in Miebo?

Active ingredient: perfluorohexyloctane (100%)

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer