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Pronunciation: ZYE-druh
Generic name: lifitegrast ophthalmic solution 5%
Dosage form: Eye drops
Drug class: Ophthalmic anti-inflammatory agents

Medically reviewed by Carmen Pope, BPharm. Last updated on Mar 26, 2024.

What is Xiidra?

Xiidra (lifitegrast 5%) is an eye drop solution that is used twice daily in each eye to treat the signs and symptoms of dry eye disease (DED) in adults over the age of 17 years.

Xiidra works by preventing a certain protein called lymphocyte function-associated antigen-1 (LFA-1) on the surface of leukocytes (a type of blood cell), from binding to a type of adhesion molecule called ICAM-1 which may be overexpressed in corneal and conjunctival tissues in people with DED. The interaction between LFA-1 and ICAM-1 is associated with T-cell activation and migration and the secretion of inflammatory cytokines. By blocking this interaction, Xiidra may prevent the secretion of inflammatory cytokines which improves the symptoms of DED, although the exact way it works in DED is not known.

Xiidra was FDA approved on July 11, 2016.


There are no contraindications to the use of Xiidra.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

Before you use Xiidra, tell your doctor if you:

Xiidra is not approved for use by anyone younger than 17 years old.

How do I use Xiidra?

Wash your hands before using the eye drops.

Do not touch the tip of the Xiidra eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.

Each container of Xiidra is for single use only. Throw away the container after putting the drops in each eye, even if some solution remains.

If you wear contact lenses, remove them before putting Xiidra drops into your eyes. You can reinsert them 15 minutes later.

Use Xiidra exactly as directed by your healthcare provider. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

What happens if I overdose?

An overdose of Xiidra is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using Xiidra?

Do not use other eye medications unless your doctor tells you to. Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Xiidra side effects

Get emergency medical help if you have signs of an allergic reaction to Xiidra, such as hives; difficulty breathing; or swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

Common Xiidra side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Xiidra?

It is not likely that other drugs will interact with Xiidra. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.


Active ingredients: lifitegrast 5% (50 mg/mL).

Inactive ingredients: sodium chloride, sodium phosphate dibasic anhydrous, sodium thiosulfate pentahydrate, sodium hydroxide, and/or hydrochloric acid (to adjust pH) and water for injection.

Supplied in a foil pouch containing 5 low-density polyethylene 0.2 mL single-use containers. Each carton holds 60 single-use containers (12 foil packets of 5 containers).


Store Xiidra eye drops at room temperature 20-25°C (68-77°F) away from moisture, heat, and light. Keep the eye drop container in its original foil pouch until you are ready to use the medicine.

Do not open the Xiidra foil pouch until you are ready to use the eye drops.

Return unused single-use containers to their original foil pouch to protect them from excessive light exposure.

Keep Xiidra and all medicines out of the reach of children.



Popular FAQ

Only use Xiidra and Restasis together if your doctor has recommended this treatment. Both drugs are used to treat dry eye disease and inflammation and you would not usually need to combine them. Both Xiidra and Restasis can be linked with similar side effects such as eye burning, stinging and irritation. Continue reading

Xiidra (lifitegrast ophthalmic) should not make dry eyes worse. If you notice a worsening of dry eyes during treatment with Xiidra, it is important to talk to your doctor about why this may be occurring and whether to try a different treatment. Continue reading

Xiidra (lifitegrast ophthalmic) will not cause diarrhea. Diarrhea is not listed as a potential side effect of using Xiidra, and there is no indication that proper administration of Xiidra in the eyes is associated with diarrhea. Continue reading

Xiidra (lifitegrast ophthalmic) should not cause hair loss. There is no indication that hair loss is a potential side effect of using Xiidra. If you do experience hair loss while using Xiidra, tell your doctor. Continue reading

Xiidra is packaged in 60 single-use containers. It is supplied in a carton that contains 12 foil pouches containing 5 low-density polyethylene 0.2 mL single-use containers per pouch. One carton should last you one month. Continue reading

Yes, you can use Xiidra (lifitegrast ophthalmic) with punctal plugs. Read on for details... Continue reading

Xiidra (generic name: lifitegrast) eye drops contains lifitegrast, a prescription medication that is classified as a lymphocyte function-associated antigen-1 (LFA-1) antagonist. Over-the-counter dry (OTC) eye products are referred to as "artificial tears" which are usually made of a combination of glycerin and propylene glycol used for the temporary relief of irritation due to dryness of the eye. Continue reading

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  1. FDA Product Label

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.