Xiidra Alternatives Compared
| Xiidra | Restasis | Tyrvaya |
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| Xiidra (lifitegrast) | Restasis (cyclosporine) | Tyrvaya (varenicline) |
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Prescription only
Xiidra is a prescription eye drop that may be used to reduce inflammation associated with dry eye disease. The main side effects are eye irritation or redness and an unusual taste in the mouth... View more |
Prescription only
Prescribed for Dry Eye Disease. Restasis may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Dry Eye Disease. Tyrvaya may also be used for purposes not listed in this medication guide. |
Related suggestions Dry Eye Disease (Keratoconjunctivitis Sicca)
Popular comparisons
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| More about Xiidra (lifitegrast) | More about Restasis (cyclosporine) | More about Tyrvaya (varenicline) | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
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No lower-cost generic available |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Xiidra has an average rating of 4.2 out of 10 from a total of 442 ratings on Drugs.com. 26% of reviewers reported a positive effect, while 55% reported a negative effect. |
Restasis has an average rating of 4.5 out of 10 from a total of 218 ratings on Drugs.com. 27% of reviewers reported a positive effect, while 49% reported a negative effect. |
Tyrvaya has an average rating of 7.6 out of 10 from a total of 24 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 13% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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See also: Xiidra side effects in more detail. |
See also: Restasis side effects in more detail. |
See also: Tyrvaya side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Xiidra prices |
View all Restasis prices and generic prices |
View all Tyrvaya prices and generic prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
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N/A |
Other cyclosporine brands include: Cequa, Verkazia, Vevye | Other varenicline brands include: Champix | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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N/A |
N/A |
24 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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No known drug interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
A total of 15 drugs are known to interact with Restasis:
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A total of 8 drugs are known to interact with Tyrvaya:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
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No known disease interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known disease interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| First Approval Date | ||||||||||||||||||||||||||
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July 11, 2016 |
December 23, 2002 |
October 15, 2021 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.