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cyclosporine (Ophthalmic route)

Pronunciation

sye-kloe-SPOR-een

Commonly used brand name(s)

In the U.S.

  • Restasis
  • Restasis Multidose

Available Dosage Forms:

  • Emulsion

Therapeutic Class: Anti-Inflammatory

Pharmacologic Class: Calcineurin Inhibitor

Uses For cyclosporine

Cyclosporine eye drops is used to increase tear production in patients who have a certain eye condition (eg, keratoconjunctivitis sicca). It belongs to a class of medicines known as immunosuppressants.

cyclosporine is available only with your doctor's prescription.

Before Using cyclosporine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For cyclosporine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to cyclosporine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of cyclosporine eye drops in children younger than 16 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of cyclosporine eye drops in the elderly.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of cyclosporine

Your eye doctor will tell you how much of cyclosporine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.

cyclosporine should come with patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions.

cyclosporine can be used with lubricant eye drops (eg, artificial tears). After putting in your artificial tears, you must wait 15 minutes before putting the cyclosporine eye drops into your eyes.

If you or your child are wearing contact lenses, remove them while you are using cyclosporine. You can reinsert your contacts 15 minutes after you put the medicine in your eyes. Talk to your eye doctor about this if you have questions.

To use:

  • First, wash your hands.
  • Rotate the vial gently back and forth before use. Do not shake the vial.
  • Tilt the head back and pressing your finger gently on the skin just beneath the lower eyelid, pull the lower eyelid away from the eye to make a space. Drop the medicine into this space. Let go of the eyelid and gently close the eyes. Do not blink.
  • If you think you did not get the drop of medicine into your eye properly, use another drop.
  • Immediately after using the eye drops, wash your hands to remove any medicine that may be on them.
  • To keep the medicine as germ free as possible, do not touch the applicator tip to any surface (including the eye).

To help clear up your eye infection completely, keep using cyclosporine for the full time of treatment, even if your symptoms have disappeared and even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon. Do not miss any doses.

Dosing

The dose of cyclosporine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of cyclosporine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For ophthalmic emulsion dosage form (eye drops):
    • To increase tear production:
      • Adults and children 16 years of age and older—Put 1 drop in each eye every 12 hours.
      • Children younger than 16 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of cyclosporine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using cyclosporine

Your eye doctor will check you or your child's eyes at regular visits to make sure if the medicine is working properly and is not causing unwanted effects.

If your or your child's symptoms do not improve or if they become worse, check with your doctor.

cyclosporine may cause blurred vision or other vision problems. If any of these occur, do not drive, use machines, or do anything else that could be dangerous if you are not able to see well.

While applying cyclosporine, your eyes will probably sting or burn for a short time. This is to be expected.

cyclosporine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Burning or other discomfort of the eye
Less common
  • Blurred vision
  • clear or yellow fluid from the eye
  • difficulty with reading
  • eye pain
  • feeling of having something in the eye
  • halos around lights
  • itching skin
  • redness of the white part of your eyes or inside of your eyelids
  • sticky or matted eyelashes
  • stinging
  • watery eye

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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