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Restasis Side Effects

Generic Name: cyclosporine ophthalmic

Note: This page contains side effects data for the generic drug cyclosporine ophthalmic. It is possible that some of the dosage forms included below may not apply to the brand name Restasis.

In Summary

Common side effects of Restasis include: burning sensation of eyes. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to cyclosporine ophthalmic: ophthalmic emulsion

As well as its needed effects, cyclosporine ophthalmic (the active ingredient contained in Restasis) may cause unwanted side effects that require medical attention.

Minor Side Effects

Some cyclosporine ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Burning or other discomfort of the eye
Less common:
  • Blurred vision
  • clear or yellow fluid from eye
  • difficulty reading
  • eye pain
  • feeling of having something in the eye
  • halos around lights
  • itching skin
  • redness of the white part of your eyes or inside of your eyelids
  • sticky or matted eyelashes
  • stinging
  • watery eye

For Healthcare Professionals

Applies to cyclosporine ophthalmic: ophthalmic emulsion


The most commonly reported side effects were ocular burning, eye pain, eye irritation, lacrimation, ocular hyperemia, and eyelid erythema.[Ref]


Very common (10% or more): Ocular burning
Common (1% to 10%): Eyelid erythema, increased lacrimation, ocular hyperemia, blurred vision, eyelid edema, conjunctival hyperemia, eye irritation, eye pain
Uncommon (0.1% to 1%): Ocular bacterial keratitis, ocular herpes zoster, conjunctival edema, lacrimal disorder, eye discharge, eye pruritus, conjunctival irritation, conjunctivitis, foreign body sensation in eyes, deposit eye, keratitis, blepharitis, corneal decompensation, chalazion, corneal infiltrates, corneal scar, eyelid pruritus, iridocyclitis, epiphora, stinging[Ref]


Postmarketing side effects include: hypersensitivity (eye swelling, urticaria, rare cases of severe angioedema, face swelling, tongue swelling, pharyngeal edema and dyspnea).[Ref]


Very common (10% or more): Instillation site pain
Common (1% to 10%): Instillation site irritation, instillation site erythema
Uncommon (0.1% to 1%): Instillation site reaction, instillation site discomfort[Ref]


1. "Product Information. Restasis (cyclosporine ophthalmic)." Allergan Inc, Irvine, CA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

It is possible that some side effects of Restasis may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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