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Xiidra Side Effects

Generic Name: lifitegrast ophthalmic

Note: This document contains side effect information about lifitegrast ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Xiidra.

For the Consumer

Applies to lifitegrast ophthalmic: ophthalmic solution

Along with its needed effects, lifitegrast ophthalmic (the active ingredient contained in Xiidra) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lifitegrast ophthalmic:

More Common

  • Changes in vision
  • eye irritation or discomfort

Less Common

  • Blurred vision
  • redness of the white part of the eyes or inside of the eyelids

Some side effects of lifitegrast ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Change in taste
  • loss of taste

Less Common

  • Cough
  • discomfort or itching of the eyes
  • drainage from the eyes
  • fever
  • headache
  • pain or tenderness around the eyes and cheekbones
  • stuffy or runny nose
  • tightness of the chest
  • troubled breathing
  • watering of the eyes

For Healthcare Professionals

Applies to lifitegrast ophthalmic: ophthalmic solution


The most commonly reported side effects included instillation site irritation, dysgeusia, and reduced visual acuity.[Ref]


Common (1% to 10%): Increased lacrimation, reduced visual acuity, blurred vision, conjunctival hyperemia, eye irritation, eye discharge/pruritus/discomfort[Ref]

Nervous system

Common (1% to 10%): Dysgeusia, headache[Ref]


Common (1% to 10%): Instillation site irritation[Ref]


Common (1% to 10%): Sinusitis[Ref]


1. "Product Information. Xiidra (lifitegrast ophthalmic)." Shire US Inc, Florence, KY.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.