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Generic name: loteprednol etabonate
Dosage form: eye (suspension) drops
Drug class: Ophthalmic steroids

Medically reviewed by Philip Thornton, DipPharm. Last updated on Sep 25, 2023.

What is Eysuvis?

Eysuvis (loteprednol etabonate) is a prescription corticosteroid eye drop used for the short-term treatment of dry eye disease.

People with dry eye disease make poor quality tears or not enough tears, which can cause red, burning and scratchy eyes. It can also cause eyes to become teary and result in blurred vision.

Eysuvis works by blocking inflammation, which is a key driver of dry eye flare-ups.

Eysuvis is a suspension eye drop that makes use of a drug delivery technology called Ampplify, which allows the medication to better penetrate the mucus barrier on your eyes, leading to increased amounts of the corticosteroid medication reaching the affected area.

Eysuvis was the first corticosteroid eye drop to be approved by the US Food and Drug Administration (FDA) for the short-term treatment of dry eye disease when it was approved in 2020.

What is Eysuvis used for?

Eysuvis is used for the short-term (up to two weeks) treatment of the signs and symptoms of dry eye disease.

Important information

Eysuvis is for use in the eyes.

Eysuvis may cause serious side effects.

Remove contact lenses before using Eysuvis. Contact lenses may be reinserted 15 minutes later.

Who should not use Eysuvis?

Do not use Eysuvis if:

What should I tell my doctor before using Eysuvis?

Before using Eysuvis, tell your healthcare provider about all your medical conditions including if you have or had:

How should I use Eysuvis?

What happens if I miss a dose?

If you miss a dose of Eysuvis then take a dose when you remember.

Dosing information

The recommended dose of Eysuvis is 1 to 2 drops into each eye four times daily for up to two weeks.

What are the side effects of Eysuvis?

Eysuvis may cause serious side effects. See "Important information" above.

The most common side effect of Eysuvis after using it for two weeks was instillation site pain, which was reported in 5 percent of patients.

This is not the only possible side effect of Eysuvis. Call your doctor for advice about side effects.

To report suspected adverse reactions, contact Kala Pharmaceuticals, Inc. at 1-833-287-KALA (1-833-287-5252) or FDA at 1-800-FDA-1088 or.


Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Pregnancy and breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant. Eysuvis should only be used during pregnancy if the benefit outweighs the risk to the fetus.

Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if Eysuvis passes into your breast milk. Talk to your doctor about the best way to feed your baby if you use Eysuvis.


Keep out of sight and reach of children.

What are the ingredients in Eysuvis?

Active ingredients: loteprednol etabonate

Inactive ingredietnts: glycerin, sodium citrate dihydrate, sodium chloride, Poloxamer 407, edetate disodium dihydrate, citric acid, and water for injection.

This medication also contains the preservative benzalkonium chloride.

Eysuvis is manufactured by Kala Pharmaceuticals, Inc. Watertown, MA 02472.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.