Varenicline Interactions
There are 65 drugs known to interact with varenicline, along with 5 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 63 are moderate, and 2 are minor.
- View all 65 medications that may interact with varenicline
- View varenicline alcohol/food interactions (1)
- View varenicline disease interactions (5)
Most frequently checked interactions
View interaction reports for varenicline and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Aspirin Low Strength (aspirin)
- Benadryl (diphenhydramine)
- Cymbalta (duloxetine)
- Eliquis (apixaban)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flexeril (cyclobenzaprine)
- Flonase (fluticasone nasal)
- Jardiance (empagliflozin)
- Lexapro (escitalopram)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- Mounjaro (tirzepatide)
- Norco (acetaminophen / hydrocodone)
- Ozempic (semaglutide)
- Seroquel (quetiapine)
- Symbicort (budesonide / formoterol)
- Trelegy Ellipta (fluticasone / umeclidinium / vilanterol)
- Trulicity (dulaglutide)
- Tylenol (acetaminophen)
- Ventolin HFA (albuterol)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D2 (ergocalciferol)
- Vitamin D3 (cholecalciferol)
- Vyvanse (lisdexamfetamine)
- Xanax (alprazolam)
- Zofran (ondansetron)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Varenicline alcohol/food interactions
There is 1 alcohol/food interaction with varenicline.
Varenicline disease interactions
There are 5 disease interactions with varenicline which include:
Report options
More about varenicline
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- Reviews (1,721)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: cholinergic agonists
- Breastfeeding
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
