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Varenicline Disease Interactions

There are 5 disease interactions with varenicline:


Varenicline (Includes varenicline) ↔ neuropsychiatric events

Severe Potential Hazard, Moderate plausibility. Applies to: History - Psychiatric Disorder, Depressive Psychosis

Serious neuropsychiatric events including, but not limited to, depression, suicidal ideation, suicide attempt, and completed suicide have been reported in patients taking varenicline. Caution is recommended and patients should be observed for neuropsychiatric symptoms including changes in behavior, hostility, agitation, depressed mood, and suicide-related events, including ideation, behavior, and attempted suicide.


Varenicline (Includes varenicline) ↔ alcoholism

Moderate Potential Hazard, Moderate plausibility. Applies to: Acute Alcohol Intoxication

Varenicline can enhance the response to alcohol and patients may experience increased intoxicating effects. In patients who may use alcohol excessively, it should be kept in mind that the potentiation may increase the danger associated with the use of alcohol. Advise patients to reduce the amount of alcohol they consume and to use caution driving or operating machinery or engaging in other potentially hazardous activities while taking varenicline until they know how this agent may affect them.


Varenicline (Includes varenicline) ↔ CV disease

Moderate Potential Hazard, Moderate plausibility. Applies to: Cardiovascular Disease, History - Myocardial Infarction, Myocardial Infarction, History - Cerebrovascular Disease

There have been reports of cardiovascular events, including ischemic and hemorrhagic events in patients taking varenicline. Caution is recommended when prescribing this agent. Patients should be monitored for signs of new or worsening symptoms of cardiovascular disease and appropriate therapy should be instituted according to medical guidelines.


Varenicline (Includes varenicline) ↔ renal impairment

Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction

Varenicline is substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Dose reduction is not required in patients with mild to moderate renal impairment. Dosage adjustment is needed in patients with severe renal impairment, and those with end-stage renal disease undergoing hemodialysis. Varenicline has been shown to be dialyzed in patients with end-stage renal disease. Monitoring of renal function is recommended.


Varenicline (Includes varenicline) ↔ seizures

Moderate Potential Hazard, Moderate plausibility. Applies to: Seizures

Seizures have been reported with varenicline therapy. Therapy with this drug should be administered with caution and monitoring is recommended in patients with a history of seizures or other factors that can lower the seizure threshold.

Varenicline drug interactions

There are 10 drug interactions with varenicline

Varenicline alcohol/food interactions

There are 2 alcohol/food interactions with varenicline

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.