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Varenicline Dosage

Medically reviewed by Drugs.com. Last updated on May 28, 2024.

Applies to the following strengths: 0.5 mg; 1 mg; 0.5 mg-1 mg; 0.03 mg/inh

Usual Adult Dose for Smoking Cessation

Days 1 to 3: 0.5 mg orally once a day
Days 4 to 7: 0.5 mg orally 2 times a day
Days 8 to end of treatment: 1 mg orally 2 times a day
Duration of therapy: 12 weeks

Comments:


Use: As an aid to smoking cessation treatment

Renal Dose Adjustments

Mild to moderate renal dysfunction (CrCl 30 mL/min or greater): No adjustment recommended.
Severe renal dysfunction (CrCl less than 30 mL/min): Recommended initial dose of 0.5 mg orally once a day; may be titrated up to a maximum dose of 0.5 mg 2 times a day
End-stage renal disease undergoing hemodialysis: A maximum dose of 0.5 mg once daily may be administered if tolerated

Liver Dose Adjustments

No adjustment recommended.

Dose Adjustments

Duration of Treatment:


Patients Unable/Unwilling to Quit Abruptly:

Quit Attempts: Patients who are motivated to quit and who do not succeed in stopping smoking during prior therapy, or who relapse after treatment, should be encouraged to make another attempt once factors contributing to the failed attempt have been identified and addressed.

Specific Populations:

Precautions

CONTRAINDICATIONS:


Safety and efficacy have not been established in children.

Consult WARNINGS section for additional precautions.

Dialysis

End-stage renal disease undergoing hemodialysis: A maximum dose of 0.5 mg once daily may be administered if tolerated
Peritoneal dialysis: Data not available

Other Comments

Administration advice:


Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.