Xarelto Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Xarelto (rivaroxaban)	Ozempic (semaglutide)	Simvastatin	Enter another drug to compare

Xarelto (rivaroxaban)

Ozempic (semaglutide)

Simvastatin

Prescription only

Xarelto limits the ability of the blood to clot and is effective at treating or preventing conditions where the risk of blood clotting is high (such as atrial fibrillation, DVT, PE); however, it may... View more

Prescription only

Ozempic lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It is... View more

Prescription only

Simvastatin is effective at lowering cholesterol; however, it may cause muscle pain, particularly at higher dosages. Should not be used by people with active liver disease or in women planning a... View more

More about Xarelto (rivaroxaban)

More about Ozempic (semaglutide)

More about Simvastatin

Ratings & Reviews

Xarelto has an average rating of 5.4 out of 10 from a total of 226 ratings on Drugs.com. 37% of reviewers reported a positive effect, while 42% reported a negative effect.

Ozempic has an average rating of 6.7 out of 10 from a total of 1560 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 23% reported a negative effect.

Simvastatin has an average rating of 4.8 out of 10 from a total of 131 ratings on Drugs.com. 30% of reviewers reported a positive effect, while 48% reported a negative effect.

View all 226 reviews

View all 1560 reviews

View all 131 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Bleeding (12.4%)
Pain (11.9%)
Headaches (11.5%)
Dizziness (10.6%)
Tiredness (8.8%)
Bruising (8.4%)
Fatigue (8.0%)

View all Xarelto side effects

Nausea (33.3%)
Diarrhea (16.3%)
Constipation (15.6%)
Vomiting (12.4%)
Burping (8.7%)
Upset stomach (7.5%)
Headaches (7.4%)

View all Ozempic side effects

Insomnia (11.5%)
Pain (11.5%)
Weakness (9.2%)
Cramps (8.4%)
Muscle pain (8.4%)
Tiredness (7.6%)
Headaches (6.9%)

View all Simvastatin side effects

Drug Class

Factor Xa inhibitors

GLP-1 Agonists (Incretin Mimetics)

Statins

Generic Availability

Lower cost generic approved

No lower cost generic approved

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	100 each
Strength	10 mg
Per unit^*	$21.38
Cost^*	$2,138.14

View all Xarelto prices

Quantity	1.5 mL
Strength	2 mg/1.5 mL (0.25 mg or 0.5 mg dose)
Per unit^*	$716.63
Cost^*	$1,074.94

View all Ozempic prices

Quantity	100 each
Strength	40 mg
Per unit^*	$0.25 - $1.53
Cost^*	$24.57 - $152.61

View all Simvastatin prices

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Dosage Forms

Oral granule for reconstitution
Oral tablet

Subcutaneous solution

Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

13 hours

168 hours

N/A

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Drug Interactions

A total of 387 drugs are known to interact with Xarelto:

135 major drug interactions (496 brand and generic names)
211 moderate drug interactions (761 brand and generic names)
41 minor drug interactions (127 brand and generic names)

A total of 274 drugs are known to interact with Ozempic:

15 major drug interactions (34 brand and generic names)
257 moderate drug interactions (1453 brand and generic names)
1 minor drug interactions (10 brand and generic names)

A total of 337 drugs are known to interact with Simvastatin:

60 major drug interactions (234 brand and generic names)
264 moderate drug interactions (687 brand and generic names)
12 minor drug interactions (59 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more
Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more

Grapefruit juice can significantly increase the blood levels of simvastatin. This can increase the... View more
Simvastatin may cause liver problems and using it with substantial quantities of alcohol may... View more

Disease Interactions

First Approval Date

N/A

December 23, 1991

WADA Class View classifications

N/A

More Information

Patient Resources

Xarelto uses

Ozempic uses

Simvastatin uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Xarelto Alternatives Compared

See also:

Cardizem

Lanoxin

Ozempic

Multaq

Digitek

Brevibloc

Edoxaban

Propafenone

Sotalol

Flecainide

Further information

Xarelto Alternatives Compared

See also:

Further information

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