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Xarelto (rivaroxaban) Disease Interactions

There are 5 disease interactions with Xarelto (rivaroxaban):


Rivaroxaban (Includes Xarelto) ↔ Bleeding

Severe Potential Hazard, Moderate plausibility

Applies to: Bleeding

The use of rivaroxaban is contraindicated in patients with active pathological bleeding. Its use increases the risk of bleeding and can cause serious or fatal bleeding. Caution is recommended when prescribing this agent to patients at increased risk of bleeding. When using this agent, the risk of thrombotic events should be weighed against the risk of bleeding.


Rivaroxaban (Includes Xarelto) ↔ Hepatic Impairment

Severe Potential Hazard, Moderate plausibility

Applies to: Liver Disease

The manufacturer recommends avoiding the use of rivaroxaban in patients with moderate and severe hepatic impairment or with any hepatic disease associated with coagulopathy as drug exposure and bleeding risk may be increased.


Rivaroxaban (Includes Xarelto) ↔ Renal Disease

Severe Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

Avoid the use of rivaroxaban in patients with CrCl <30 mL/min. Observe closely and promptly evaluate any signs or symptoms of blood loss in patients with CrCl 30 to 50 mL/min. Treatment should be discontinued in patients who develop acute renal failure while on rivaroxaban.


Rivaroxaban (Includes Xarelto) ↔ Unstable Blood Pressure

Severe Potential Hazard, Moderate plausibility

Applies to: Hypotension

Initiation of rivaroxaban is not recommended acutely as an alternative to unfractionated heparin in patients with pulmonary embolism who present with hemodynamic instability or who may receive thrombolysis or pulmonary embolectomy.


Rivaroxaban (Includes Xarelto) ↔ Valvular Heart Disease

Severe Potential Hazard, Moderate plausibility

Applies to: Valvular Heart Disease

The use of rivaroxaban is not recommended in patients with prosthetic heart valves as no studies have been conducted for safety and efficacy.

Xarelto (rivaroxaban) drug Interactions

There are 356 drug interactions with Xarelto (rivaroxaban)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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