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Xarelto (rivaroxaban) Drug Interactions

A total of 395 drugs are known to interact with Xarelto (rivaroxaban).

  • 186 major drug interactions
  • 201 moderate drug interactions
  • 8 minor drug interactions

Show all medications in the database that may interact with Xarelto (rivaroxaban).

Check for interactions with Xarelto (rivaroxaban)

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Common medications checked in combination with Xarelto (rivaroxaban)

  • Advil (ibuprofen)
  • amlodipine (Norvasc)
  • aspirin (Aspir 81, Ecotrin, Acetylsalicylic Acid, Aspirin Low Strength, Bayer Aspirin, Aspir-Low, Ascriptin, Bufferin, Ecotrin Adult Low Strength, Arthritis Pain, Fasprin, Halfprin, Aspiritab, Easprin, Aspergum, Durlaza, St. Joseph 81 mg Chewable Aspirin, Empirin, Buffered Aspirin, Ecotrin Maximum Strength, Ascriptin Enteric, Migralex, Aspi-Cor, Aspirtab, Low Dose ASA, Bufferin Extra Strength, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Bayer Aspirin Regimen, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Bufferin Low Dose, Medi-Seltzer, Sloprin, ZORprin, Bayer Children's Aspirin, Bayer Aspirin Extra Strength Plus, Buffex, Entercote, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Therapy Bayer, St. Joseph Aspirin, Stanback Analgesic, Norwich Aspirin, Acuprin 81, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Aspirin Lite Coat, Heartline, Bayer Advanced Aspirin, Buffasal)
  • atorvastatin (Lipitor)
  • Benadryl (diphenhydramine)
  • carvedilol (Coreg, Coreg CR)
  • Celebrex (celecoxib)
  • Cialis (tadalafil)
  • furosemide (Lasix, Diaqua-2, Lo-Aqua)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • hydrochlorothiazide (HydroDIURIL, Microzide, Oretic, Esidrix, Ezide, Hydro Par, Carozide, Diaqua, Loqua, Aquazide H)
  • ibuprofen (Advil, Motrin, IBU, Children's Motrin, Advil Liqui-Gels, Proprinal, IBU-200, Motrin IB, Advil Migraine, Ibu-8, Motrin Childrens, Caldolor, Ibuprofen PMR, Nuprin, Childrens Ibuprofen Berry, Motrin Migraine Pain, Addaprin, NeoProfen, Advil Infant's Concentrated Drops, Ibu-Tab, Rufen, Genpril, Motrin Infant Drops, Haltran, Menadol, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Advil Children's, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Unithroid, Euthyrox, Levothyrox, Eutroxsig, Oroxine, Levo-T, Levotabs, L Thyroxine Roche, Novothyrox, Tirosint-Sol, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • losartan (Cozaar)
  • Lovenox (enoxaparin)
  • metformin (Glucophage, Glumetza, Glucophage XR, Fortamet, Riomet)
  • metoprolol (Metoprolol Tartrate, Metoprolol Succinate ER, Lopressor, Toprol-XL, Kapspargo Sprinkle)
  • Metoprolol Succinate ER (metoprolol)
  • Metoprolol Tartrate (metoprolol)
  • naproxen (Aleve, Naprosyn, Anaprox, Naproxen Sodium DS, Anaprox-DS, Naprelan, EC-Naprosyn, Comfort Pac with Naproxen, Leader Naproxen Sodium, Pamprin All Day Relief, Aflaxen, Midol Extended Relief, Flanax Pain Reliever, All Day Pain Relief, All Day Relief)
  • Norco (acetaminophen / hydrocodone)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • pantoprazole (Protonix, Protonix IV)
  • Peri-DS (casanthranol / docusate)
  • Plavix (clopidogrel)
  • potassium chloride (Klor-Con, KCl, K-Dur, Micro-K, K-Tab, Klor-Con M10, Klor-Con M20, Kay Ciel, K-Lor, Kal Potassium 99, Slow-K, Kaon-CI, Klor-Con 8, K-Dur 20, Klotrix, Klor-Con Sprinkle, Cena K, K-8, Klor-Con 10, Epiklor, Kaochlor, K-Norm, Micro-K 10, Kaochlor S-F, Kaon-CL 20%, K-Sol, K + Potassium, Klor-Con/25, K-10, Glu-K, K-Dur 10, Kaon-CL 10, Kato, Ed K+10, PC-10, Ten-K, Klor-Con M15, K-Vescent (Potassium Chloride), K+Care, Klorvess, Rum-K, Gen-K)
  • prednisone (Deltasone, Sterapred, Rayos, Sterapred DS, Prednicot, Orasone, Meticorten, Liquid Pred, Prednicen-M)
  • simvastatin (Zocor, FloLipid)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, ConZip, Larapam SR, Ryzolt, Tramal SR, GenRx Tramadol, Zamadol, Tramedo, Zydol, Tramahexal SR, Tramahexal, Zydol XL, Rybix ODT, Ultram ODT)
  • Tylenol (acetaminophen)
  • Viagra (sildenafil)
  • Vitamin D3 (cholecalciferol)
  • Vitamin K (phytonadione)

Xarelto (rivaroxaban) disease interactions

There are 5 disease interactions with Xarelto (rivaroxaban) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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