Wegovy Dosage

Generic name: SEMAGLUTIDE 0.25mg in 0.5mL
Dosage form: injection, solution
Drug class: GLP-1 Agonists (Incretin Mimetics)

Medically reviewed by Drugs.com. Last updated on Nov 1, 2024.

•: In patients with type 2 diabetes, monitor blood glucose prior to starting WEGOVY and during WEGOVY treatment.
•: Prior to initiation of WEGOVY, train patients on proper injection technique. Refer to the accompanying Instructions for Use for complete administration instructions with illustrations.
•: Inspect WEGOVY visually prior to each injection. Only use if solution is clear, colorless, and contains no particles.
•: Administer WEGOVY in combination with a reduced-calorie diet and increased physical activity.
•: Administer WEGOVY once weekly, on the same day each week, at any time of day, with or without meals.
•: Inject WEGOVY subcutaneously in the abdomen, thigh, or upper arm. The time of day and the injection site can be changed without dose adjustment.

Dosage Initiation and Escalation

•: Initiate WEGOVY with a dosage of 0.25 mg injected subcutaneously once weekly. Then follow the dose escalation schedule presented in Table 1 to minimize gastrointestinal adverse reactions.
•: If patients do not tolerate a dose during dosage escalation, consider delaying dosage escalation for 4 weeks.

Table 1. Recommended Dosage Regimen for Adults

Treatment	Weeks	Once weekly Subcutaneous Dosage
Initiation	1 through 4	0.25 mg
Escalation	5 through 8	0.5 mg
	9 through 12	1 mg
	13 through 16	1.7 mg
Maintenance	17 and onward	1.7 mg or 2.4 mg

Maintenance Dosage

•: The maintenance dosage of WEGOVY in adults is either 2.4 mg (recommended) or 1.7 mg once weekly. Consider treatment response and tolerability when selecting the maintenance dosage.

Dosage Initiation and Escalation

•: Initiate WEGOVY according to the dosage escalation schedule in Table 2 to minimize gastrointestinal adverse reactions.
•: If patients do not tolerate a dose during dosage escalation, consider delaying dosage escalation for 4 weeks.
•: The 0.25 mg, 0.5 mg, and 1 mg once-weekly dosages are initiation and escalation dosages and are not approved as maintenance dosages.
Table 2. Recommended Dosage Regimen for Pediatric Patients Aged 12 Years and Older

Treatment	Weeks	Once weekly Subcutaneous Dosage
Initiation	1 through 4	0.25 mga
Escalation	5 through 8	0.5 mga
	9 through 12	1 mga
	13 through 16	1.7 mgb
Maintenance	17 and onward	2.4 mg

aNot approved as maintenance dosages
bSee Dosage Modifications for Adverse Reactions

Maintenance Dosage

•: The maintenance dosage of WEGOVY in pediatric patients aged 12 years and older is 2.4 mg once weekly.

Dosage Modifications for Adverse Reactions

•: If patients do not tolerate the 2.4 mg once-weekly maintenance dosage, the maintenance dosage may be reduced to 1.7 mg once weekly.
•: Discontinue WEGOVY if the patient cannot tolerate the 1.7 mg once-weekly dosage.

•: If one dose is missed and the next scheduled dose is more than 2 days away (48 hours), administer WEGOVY as soon as possible. If one dose is missed and the next scheduled dose is less than 2 days away (48 hours), do not administer the dose. Resume dosing on the regularly scheduled day of the week.
•: If 2 or more consecutive doses are missed, resume dosing as scheduled or, if needed, reinitiate WEGOVY and follow the dose escalation schedule, which may reduce the occurrence of gastrointestinal symptoms associated with reinitiation of treatment.