Wegovy Dosage

Important Monitoring and Administration Instructions

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In patients with type 2 diabetes mellitus, monitor blood glucose prior to starting WEGOVY and during WEGOVY treatment.

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Prior to initiation of WEGOVY, train patients on proper injection technique. Refer to the accompanying Instructions for Use for complete administration instructions with illustrations.

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Inspect WEGOVY visually prior to each injection. Only use if solution is clear, colorless, and contains no particles.

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Administer WEGOVY in combination with a reduced-calorie diet and increased physical activity.

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Administer WEGOVY once weekly, on the same day each week, at any time of day, with or without meals.

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Inject WEGOVY subcutaneously in the abdomen, thigh, or upper arm. The time of day and the injection site can be changed without dose adjustment.

Recommended Dosage Initiation and Escalation Schedule

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Initiate WEGOVY with a dosage of 0.25 mg injected subcutaneously once weekly. Follow the recommended dosage initiation and escalation in Table 1 for all indications to reduce the risk of gastrointestinal adverse reactions.

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If patients do not tolerate a dose during dosage escalation, consider delaying dosage escalation for 4 weeks.

​Table 1. Recommended Dosage Initiation and Escalation

Recommended Maintenance Dosage

Cardiovascular Risk Reduction and Weight Reduction

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The maintenance dosage of WEGOVY for CV risk reduction and weight reduction is either 2.4 mg (recommended) or 1.7 mg injected subcutaneously once weekly.

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Consider treatment response and tolerability when selecting the maintenance dosage.

​Noncirrhotic MASH with Moderate to Advanced Liver Fibrosis

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​The recommended maintenance dosage of WEGOVY for the treatment of noncirrhotic MASH with moderate to advanced liver fibrosis is 2.4 mg injected subcutaneously once weekly.

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​If patients do not tolerate the maintenance dosage of 2.4 mg once weekly, the dosage can be decreased to 1.7 mg once weekly. Consider reescalation to 2.4 mg once weekly​.

Recommendations Regarding Missed Dose

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If one dose is missed and the next scheduled dose is more than 2 days away (48 hours), administer WEGOVY as soon as possible. If one dose is missed and the next scheduled dose is less than 2 days away (48 hours), do not administer the dose. Resume dosing on the regularly scheduled day of the week.

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If 2 or more consecutive doses are missed, resume dosing as scheduled or, if needed, reinitiate WEGOVY and follow the dose escalation schedule, which may reduce the occurrence of gastrointestinal symptoms associated with reinitiation of treatment.