Wellbutrin XL Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Wellbutrin XL (bupropion)	Rexulti (brexpiprazole)	Bupropion	Enter another drug to compare

Wellbutrin XL (bupropion)

Rexulti (brexpiprazole)

Bupropion

Prescription only

Prescribed for Major Depressive Disorder, Depression, Seasonal Affective Disorder. Wellbutrin XL may also be used for purposes not listed in this medication guide.

Prescription only

Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression, or used to relieve agitation associated with dementia in Alzheimer's disease. Most people... View more

Prescription only

Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more

More about Wellbutrin XL (bupropion)

More about Rexulti (brexpiprazole)

More about Bupropion

Ratings & Reviews

Wellbutrin XL has an average rating of 7.5 out of 10 from a total of 494 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 16% reported a negative effect.

Rexulti has an average rating of 6.6 out of 10 from a total of 499 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 25% reported a negative effect.

Bupropion has an average rating of 7.0 out of 10 from a total of 2913 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 20% reported a negative effect.

View all 494 reviews

View all 499 reviews

View all 2913 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Anxiety (16.2%)
Insomnia (10.5%)
Loss of appetite (7.9%)
Headaches (7.7%)
Anger (5.7%)
Irritability (5.7%)
Depression (5.3%)

View all Wellbutrin XL side effects

Weight gain (21.8%)
Anxiety (9.2%)
Insomnia (7.6%)
Restlessness (6.4%)
Tiredness (6.0%)
Increased appetite (4.8%)
Depression (4.4%)

View all Rexulti side effects

Anxiety (16.4%)
Insomnia (11.7%)
Headaches (7.2%)
Sexual dysfunction (6.3%)
Irritability (6.2%)
Depression (5.6%)
Loss of appetite (5.6%)

View all Bupropion side effects

Drug Class

Miscellaneous antidepressants

Atypical antipsychotics

Generic Availability

Lower cost generic approved

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	30 tablet, extended release
Strength	150 mg/24 hours
Per unit^*	$71.73
Cost^*	$2,151.87

View all Wellbutrin XL prices

Quantity	30 tablet
Strength	0.25 mg
Per unit^*	$49.61
Cost^*	$1,488.43

View all Rexulti prices

Quantity	30 each
Strength	150 mg/24 hours
Per unit^*	$0.48
Cost^*	$14.40

View all Bupropion prices

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Dosage Forms

Oral tablet, extended release

Oral tablet

Oral tablet
Oral tablet, extended release

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

30 hours

91 hours

30 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 560 drugs are known to interact with Wellbutrin XL:

218 major drug interactions (953 brand and generic names)
337 moderate drug interactions (1877 brand and generic names)
5 minor drug interactions (16 brand and generic names)

A total of 601 drugs are known to interact with Rexulti:

136 major drug interactions (610 brand and generic names)
462 moderate drug interactions (1722 brand and generic names)
3 minor drug interactions (9 brand and generic names)

A total of 560 drugs are known to interact with Bupropion:

218 major drug interactions (953 brand and generic names)
337 moderate drug interactions (1877 brand and generic names)
5 minor drug interactions (16 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more

Alcohol can increase the nervous system side effects of brexpiprazole such as dizziness... View more

Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more

Disease Interactions

First Approval Date

August 28, 2003

July 10, 2015

December 30, 1985

WADA Class View classifications

N/A

More Information

Patient Resources

Wellbutrin XL uses

Rexulti uses

Bupropion uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Wellbutrin XL Alternatives Compared

See also:

Vraylar

Auvelity

Rexulti

Lexapro

Zoloft

Seroquel

Prozac

Cymbalta

Wellbutrin

Duloxetine

Further information

Wellbutrin XL Alternatives Compared

See also:

Further information

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