Wellbutrin XL Alternatives Compared
| Wellbutrin XL | Cymbalta | Bupropion |
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| Wellbutrin XL bupropion | Cymbalta duloxetine | Bupropion |
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Prescribed for Major Depressive Disorder, Depression, Seasonal Affective Disorder. Wellbutrin XL may also be used for purposes not listed in this medication guide. |
Cymbalta has antidepressant, anti-anxiety, and pain-relieving properties; however, it has been associated with a discontinuation syndrome on withdrawal even when tapered. Prescribed for Back Pain... View more |
Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more |
Choose a suggestion below Depression
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| More about Wellbutrin XL (bupropion) | More about Cymbalta (duloxetine) | More about Bupropion | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
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Prescription only |
Prescription only |
Prescription only |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Wellbutrin XL has an average rating of 7.4 out of 10 from a total of 404 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 16% reported a negative effect. |
Cymbalta has an average rating of 6.3 out of 10 from a total of 1655 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 30% reported a negative effect. |
Bupropion has an average rating of 7.0 out of 10 from a total of 2560 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 20% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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Common side effects include: dizziness, insomnia, nausea, pharyngitis, weight loss, xerostomia. See the full Wellbutrin XL side effects document. |
Common side effects include: asthenia, constipation, diarrhea, dizziness, drowsiness, fatigue, hypersomnia, insomnia, nausea, sedated state, headache, xerostomia. See the full Cymbalta side effects document. |
Commonly reported side effects include: insomnia, nausea, pharyngitis, weight loss, constipation, dizziness, headache, xerostomia. See the full bupropion side effects document. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Wellbutrin XL prices and generic prices |
View all Cymbalta prices and generic prices |
View all bupropion prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR | Other duloxetine brands include: Drizalma Sprinkle, Irenka | Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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30 hours |
17 hours |
30 hours |
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| CSA Schedule** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 425 drugs are known to interact with Wellbutrin XL:
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A total of 573 drugs are known to interact with Cymbalta:
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A total of 425 drugs are known to interact with bupropion:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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August 28, 2003 |
N/A |
December 30, 1985 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.