Wellbutrin XL Alternatives Compared
| Wellbutrin XL | Bupropion | Cymbalta |
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| Wellbutrin XL (bupropion) | Bupropion | Cymbalta (duloxetine) |
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Prescription only
Prescribed for Major Depressive Disorder, Depression, Seasonal Affective Disorder. Wellbutrin XL may also be used for purposes not listed in this medication guide. |
Prescription only
Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more |
Prescription only
Cymbalta has antidepressant, anti-anxiety, and pain-relieving properties; however, it has been associated with a discontinuation syndrome on withdrawal even when tapered. Prescribed for Back Pain... View more |
Related suggestions Depression
Major Depressive Disorder
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| More about Wellbutrin XL (bupropion) | More about Bupropion | More about Cymbalta (duloxetine) | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Wellbutrin XL has an average rating of 7.5 out of 10 from a total of 481 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 16% reported a negative effect. |
Bupropion has an average rating of 7.0 out of 10 from a total of 2825 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 21% reported a negative effect. |
Cymbalta has an average rating of 6.2 out of 10 from a total of 1866 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 30% reported a negative effect. |
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| Side Effects | ||||||||||||||||||||||||||
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See also: Wellbutrin XL side effects in more detail. |
See also: bupropion side effects in more detail. |
See also: Cymbalta side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Wellbutrin XL prices and generic prices |
View all bupropion prices |
View all Cymbalta prices and generic prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR | Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL | Other duloxetine brands include: Drizalma Sprinkle, Irenka | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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30 hours |
30 hours |
17 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 492 drugs are known to interact with Wellbutrin XL:
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A total of 492 drugs are known to interact with bupropion:
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A total of 585 drugs are known to interact with Cymbalta:
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| First Approval Date | ||||||||||||||||||||||||||
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August 28, 2003 |
December 30, 1985 |
N/A |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient resources | ||||||||||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.