Wellbutrin XL Alternatives Compared
| Wellbutrin XL (bupropion) | Rexulti (brexpiprazole) | Bupropion |
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| Wellbutrin XL (bupropion) | Rexulti (brexpiprazole) | Bupropion |
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Prescription only
Prescribed for Major Depressive Disorder, Depression, Seasonal Affective Disorder. Wellbutrin XL may also be used for purposes not listed in this medication guide. |
Prescription only
Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression, or used to relieve agitation associated with dementia in Alzheimer's disease. Most people... View more |
Prescription only
Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more |
Related suggestions Depression
Major Depressive Disorder
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| More about Wellbutrin XL (bupropion) | More about Rexulti (brexpiprazole) | More about Bupropion | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Wellbutrin XL has an average rating of 7.5 out of 10 from a total of 492 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 15% reported a negative effect. |
Rexulti has an average rating of 6.6 out of 10 from a total of 484 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 26% reported a negative effect. |
Bupropion has an average rating of 7.1 out of 10 from a total of 2898 ratings on Drugs.com. 62% of reviewers reported a positive effect, while 20% reported a negative effect. |
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| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Wellbutrin XL prices |
View all Rexulti prices |
View all Bupropion prices |
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| Dosage Forms Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR |
N/A |
Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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30 hours |
91 hours |
30 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 526 drugs are known to interact with Wellbutrin XL:
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A total of 596 drugs are known to interact with Rexulti:
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A total of 526 drugs are known to interact with Bupropion:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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| First Approval Date | ||||||||||||||||||||||||||
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August 28, 2003 |
July 10, 2015 |
December 30, 1985 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| Patient resources | ||||||||||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.