Comparing Bupropion vs Wellbutrin XL

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Bupropion

Wellbutrin XL bupropion

Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more

Prescribed for Major Depressive Disorder, Depression, Seasonal Affective Disorder. Wellbutrin XL may also be used for purposes not listed in this medication guide.

Prescription only

Ratings & Reviews

View all 2419 reviews

View all 387 reviews

Drug Class

Miscellaneous antidepressants

Side Effects

Commonly reported side effects include: insomnia, nausea, pharyngitis, weight loss, constipation, dizziness, headache, and xerostomia.

See the full bupropion side effects document.

Common side effects include: dizziness, insomnia, nausea, pharyngitis, weight loss, and xerostomia.

See the full Wellbutrin XL side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	30 each
Dosage	150 mg/24 hours
Per Unit^*	$1.64
Cost^*	$49.22

View all bupropion prices

Quantity	30 tablet, extended release
Dosage	150 mg/24 hours
Per Unit^*	$55.51
Cost^*	$1,665.16

View all Wellbutrin XL prices and generic prices

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Generic Availability

Yes (this medicine)

Yes

Dosage Form(s) Available

Oral tablet
Oral tablet, extended release

Oral tablet, extended release

Brand Names

Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

30 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 423 drugs are known to interact with bupropion:

212 major drug interactions (924 brand and generic names)
206 moderate drug interactions (862 brand and generic names)
5 minor drug interactions (16 brand and generic names)

A total of 423 drugs are known to interact with Wellbutrin XL:

212 major drug interactions (924 brand and generic names)
206 moderate drug interactions (862 brand and generic names)
5 minor drug interactions (16 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more

Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more

Disease Interactions

First Approval Date

December 30, 1985

August 28, 2003

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Advanced Reading

Professional Resources

Prescribing Information

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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