Comparing Rybelsus vs Metformin
| Rybelsus (semaglutide) | Metformin |
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| Rybelsus (semaglutide) | Metformin |
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Prescription only
Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more |
Prescription only
Metformin improves how the body responds to insulin and it is used to treat type 2 diabetes. Taste disturbances, diarrhea, and other stomach-related side effects are common side effects. Metformin is... View more |
Related suggestions Type 2 Diabetes
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| More about Rybelsus (semaglutide) | More about Metformin | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Rybelsus has an average rating of 6.4 out of 10 from a total of 286 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 23% reported a negative effect. |
Metformin has an average rating of 6.8 out of 10 from a total of 655 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 19% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Rybelsus side effects |
View all Metformin side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Rybelsus prices |
View all Metformin prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other semaglutide brands include: Ozempic, Wegovy | Glumetza | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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168 hours |
4.5 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 273 drugs are known to interact with Rybelsus:
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A total of 377 drugs are known to interact with Metformin:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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September 20, 2019 |
March 03, 1995 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.