Retin-A Alternatives Compared
| Retin-A | Doxycycline | Spironolactone |
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| Retin-A (tretinoin) | Doxycycline | Spironolactone |
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Prescription only
Prescribed for Photoaging of the Skin, Lichen Sclerosus, Acne. May also be prescribed off label for Necrobiosis Lipoidica Diabeticorum. |
Prescription only
Doxycycline is an effective antibiotic that treats a wide range of infections. However, it is not usually recommended for children aged less than eight or pregnant women in the last half of their... View more |
Prescription only
Spironolactone is a diuretic that may be used to remove excess fluid (edema) from the body, lower blood pressure, or treat hyperaldosteronism. It does not cause potassium loss from the body; however... View more |
Related suggestions Popular comparisons
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| More about Retin-A (tretinoin) | More about Doxycycline | More about Spironolactone | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Retin-A has an average rating of 8.1 out of 10 from a total of 97 ratings on Drugs.com. 79% of reviewers reported a positive effect, while 12% reported a negative effect. |
Doxycycline has an average rating of 6.4 out of 10 from a total of 1608 ratings on Drugs.com. 50% of reviewers reported a positive effect, while 26% reported a negative effect. |
Spironolactone has an average rating of 6.9 out of 10 from a total of 680 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 25% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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See also: Retin-A side effects in more detail. |
See also: doxycycline side effects in more detail. |
See also: spironolactone side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Retin-A prices and generic prices |
View all doxycycline prices |
View all spironolactone prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Other tretinoin brands include: Altinac, Altreno, Atralin, Avita, Obagi, Refissa, Renova, Retin A Micro, Retin-A and Renova View more | Acticlate, Adoxa, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Doryx MPC, Doxy 100, Doxy 200, Doxy-Caps, Doxy-D, LymePak, Mondoxyne NL, Monodox, Morgidox, Okebo, Oracea, Oraxyl, Targadox, Uracil, Vibramycin View more | Aldactone, CaroSpir | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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N/A |
23 hours |
37 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category D
Positive evidence of risk
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 12 drugs are known to interact with Retin-A:
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A total of 195 drugs are known to interact with doxycycline:
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A total of 371 drugs are known to interact with spironolactone:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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October 20, 1971 |
December 05, 1967 |
January 21, 1960 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
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| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.