Tretinoin use while Breastfeeding
Drugs containing Tretinoin: Retin-A, Atralin, Altreno, Retin A Micro, Renova, Veltin, Tri-Luma, Ziana, Avita, Refissa, Show all 20 »Vesanoid, Solage, Retisol-A, Tretin-X, Stieva-A, Obagi, Vitinoin, Altinac, Stieva-A Forte, Retin-A and Renova
Medically reviewed by Drugs.com. Last updated on Dec 2, 2018.
Tretinoin Levels and Effects while Breastfeeding
Summary of Use during Lactation
Tretinoin has not been studied during breastfeeding. Breastfeeding should probably be avoided after oral use. Because it is poorly absorbed after topical application, it is considered a low risk to the nursing infant. Ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
A review of adverse reaction reports on retinoids causing a breast reaction submitted to a French pharmacovigilance center found 1 case of gynecomastia was associated with topical tretinoin use.
Alternate Drugs to Consider
1. Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006;24:167-97. PMID: 16677965
2. Zip C. Common sense dermatological drug suggestions for women who are breast-feeding. Skin Therapy Lett. 2002;7:5-7. PMID: 12007012
3. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II Lactation. J Am Acad Dermatol. 2014;70:417.e1-417.e10. PMID: 24528912
4. Noti A, Grob K, Biedermann M et al. Exposure of babies to C(15)-C(45) mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003;38:317-25. PMID: 14623482
5. Atzenhoffer M, Pierre S, Bellet F et al. Gynecomastia and galactorrhea: Unlabeled adverse drug reactions of retinoids used in dermatology. Drug Safety. 2018;41:1198-9. Abstract. DOI: doi:10.1007/s40264-018-0719-2
CAS Registry Number
LactMed Record Number
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