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Retin-A and Pain: What Users Say

Pain: mentioned by 7 users (7.2%)

Based on user experiences from 97 Retin-A reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

acne 27.8%
peeling 19.6%
dry skin 11.3%
dryness 10.3%
pain 7.2%
burning 6.2%
irritation 5.2%
redness 5.2%
vomiting 4.1%
scarring 3.1%

Reviews for Retin-A

Commonly mentioned side effects
  • Cal...
  • June 23, 2015

For Acne "I wanted to take the time to write a review in the hopes to give at least one person the self-confidence boost they need to keep going with Retin-A. I've been waiting for the day I get to write my own review. I officially started using Retin-A 0.25 just under 4 months ago today. My first day was 3 weeks before my birthday. I remember contacting my derm in advance with a million questions and mostly the fear of going through THE PURGE during this busy time filled with celebrations, events, etc. I thankfully made the gamble and started! I decided it was always be... I'll start next week, next month. Let's be real, when is there ever a good time for acne?! I can only describe the last 4 months as a rollercoaster. There will be good days. There will be days you hide inside. At some points I thought I was done purging, then it would come back. IT TAKES TIME. Painful cysts too, that do not go away. I would rather have 20 whitehead pimples all over than 1 deep painful cyst on my face! It was the most challenging thing I've gone through. It will test your patience. To the point of tears, and whys me's! At one point I scheduled an emergency derm appt to receive Cortizon injections on 3 cysts that were almost the size of dimes!! I couldn't take it anymore. This was 2.5 months. He sat me down and said it takes 3-4 months for results to be reached and you will hate your derm for that time and gave me the push to continue to go forward. Here's the good news! I am at my 4-month mark, and I have never been more happy. I haven't had a breakout in 1.5 weeks. I don't know the last time I've been able to say that. I can take on the CALI summer and not feel like I'm hiding. My biggest advice is be strong! Tell yourself every day, it's only 4 months of the rest of your life. Get past the 4-5 month mark and it will all be worth it! The past will be a blur! Good luck and you can do it!"

9 / 10
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  • AG1...
  • Taken for 1 to 6 months
  • June 16, 2013

For Photoaging of the Skin "I'm using Retin-A 0.025 gel version of tretinoin. My review is more of an encouragement rather than a full review. My full review will happen after at least a year of usage. Current usage - 2 months. So, you see, within 2 months of usage already deserves an 8 score rating from me. I could easily give it higher, but I'd rather wait for my full review. Now, I have read many of what the users said here and on the internet. It will be best for new users not to pay too much attention to users below 2 months of usage. Because all you hear is pain, breakout, worries, and eventually the key way they use = give up. It's your choice. But please read those who have actually used tretinoin for at least 6 months."

8 / 10
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250 Report
  • Ann...
  • Taken for 1 to 6 months
  • August 6, 2016

For Acne "I have posted early before about my 1st and 2nd week using Retin-A 0.025 cream. My 3rd week was much better than my second week, some of my acne started to calm down, and my face felt less bumpy. During this week, I started to use the cream 4 times a week because my cheeks were hurting. My 4th week was the most improvement. I started to use the cream every night again since my face had stopped hurting. During the 4th week, most of my pimples disappeared, and my skin felt smoother. I still had some pimples popping up, but not as much. Now my cheeks are pretty smooth with a couple of pimples, but my cheeks are really red from the scars that were left behind from the pimples. I'm hoping they will slowly fade later. Will keep updating!"

9 / 10
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36 Report

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Frequently asked questions

  • Tan...
  • Taken for 6 months to 1 year
  • March 25, 2019

For Acne "In the first 3-4 weeks on Retin-A, it was horrible, I had horrible acne almost everywhere on my face, especially on my cheeks, and it's painful. But after 1 or 2 months, I noticed a big improvement on my face. Trust me, it's worth trying."

8 / 10
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24 Report
  • An0...
  • July 21, 2016

For Acne "(Female/moderate acne) I have suffered from acne since I was 12. This summer has been the worst for my face. I have acne all over my forehead and my cheeks. In the beginning of the summer, I had small, tiny bumps all over my forehead and my cheeks that later became bigger. I've used many, many products on my face that worked quite a bit to not working at all. Then, in the beginning of July, I started using Retin-A 0.025 cream. The first week showed great results on my forehead, my forehead is now clear, but my cheeks became worse. This second week that I am currently in is what I guess is the purge, my cheeks are entirely red and covered in acne. I don't want to go outside, and my cheeks really hurt. Will keep updating. Not losing hope."

7 / 10
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26 Report

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  • An0...
  • Taken for 1 to 6 months
  • August 5, 2016

For Acne "I have posted earlier before about my 1st and 2nd week using Retin-A 0.025 cream. My 3rd week was much better than my second week, some of my acne started to calm down, and my face felt less bumpy. During this week, I started to use the cream 4 times a week because my cheeks were hurting. My 4th week showed the most improvement. I started to use the cream every night again since my face had stopped hurting. During the 4th week, most of my pimples disappeared, and my skin felt smoother. I still had some pimples popping up, but not as much. Now my cheeks are pretty smooth with a couple of pimples, but my cheeks are really red from the scars that were left behind from the pimples. I'm hoping they will slowly fade later. Will keep updating!"

9 / 10
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4 Report
  • Jen...
  • Taken for 1 to 6 months
  • March 5, 2019

For Acne "I started using Retin-A after switching my birth control pills to progesterone only due to severe migraines thought to be caused by estrogen. I am now 23 and never struggled this bad with acne. Before Retin-A, I had a few cystic acne spots on my chin and jawline and small blemishes on my forehead occasionally. After using Retin-A, my face got way worse. The first week, it caused my face to be red, flaky, and burn. This wasn't the typical burning feeling I would get from a topical acne cream. This was a burn that would hurt when I would step outside. It made the cystic acne spots really dry, red, and very sore. I called my dermatologist, and they said those are typical side effects and to mix my moisturizer with the Retin-A. This helped but didn't help enough. I went another 5+ weeks dealing with peeling, flaking, red, irritated, dry, sore skin. I finally decided to stop using it. The next day, my skin was feeling a lot less sore and irritated. This was not the medication for me."

1 / 10
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10 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.