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Retin-A and Peeling: What Users Say

Peeling: mentioned by 19 users (19.6%)

Based on user experiences from 97 Retin-A reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

acne 27.8%
peeling 19.6%
dry skin 11.3%
dryness 10.3%
pain 7.2%
burning 6.2%
irritation 5.2%
redness 5.2%
vomiting 4.1%
scarring 3.1%

Reviews for Retin-A

Commonly mentioned side effects
  • DDF...
  • Taken for 10 years or more
  • April 30, 2018

For Acne "I am a 72-year-old woman who has been using Retin-A for thirty-four years. I started using it because I had adult acne at the same time my teenage son had acne. I routinely am mistaken for being twenty years younger than I am. I have very few wrinkles. My skin still has dry patches occasionally but they are short-lived. I have tried to get several people to use it, but they always get discouraged with the redness and peeling in the beginning. This phase does not last forever. Please continue to use it, you will never be sorry."

10 / 10
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  • Nii...
  • Taken for 1 to 6 months
  • February 1, 2020

For Acne "Okay, been on Retin-A since early November. Prescribed by my primary care physician prior to seeing a dermatologist. When I first began, I started using the gel two times a week. Making sure to always wash off in the morning and use sunscreen throughout the day. I was afraid of the purging period which THANK GOD, I never had. It almost felt like the medication wasn't working. I had no burning or stinging sensations, just minor peeling, which was not bad AT ALL. This could be because I am on the lowest dosage (0.025). I upped my usage to three times a week and kept using it despite feeling like anything was working. Fast forward to today, three months later, and my skin is sooooooo smooth. I still have fading dark marks, but they are significantly lighter. I have ZERO ACTIVE ACNE bumps. Smooth skin and very shiny. I am a 25 y/o African American female, and THIS PRODUCT IS GREAT. Patience is KEY!!!!"

9 / 10
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86 Report
  • Jos...
  • December 29, 2013

For Acne "So, about five months ago, I asked my esthetician for some Retin-A (tretinoin) cream, and she gave me the 1% concentration. I had moderate acne when I was younger, but I didn't leave it alone. Haha. I picked at it, and so I have some 'mild' (Or so I'm told - I think it's terrible!) scarring now, even though my acne went away with age. I'm 25 now. Acne went away at about 19. Some are pockmarks, and others just discoloration and a little uneven texture. I jumped straight to everyday use. Expected irritation and redness, but none came. My (sensitive) skin handled it awesomely. Product works great. Skin peels off every morning. Haha. Scars are fading nicely. Pockmarks much less depressed. I get compliments on my skin now!"

10 / 10
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113 Report

Frequently asked questions

  • Pea...
  • October 11, 2019

For Acne "This medication, Retin-A, has been a life changer for me. I was at an appointment, and I was complaining about hormonal acne flares before my period. My doctor started telling me about what Retin-A had done for her hormonal acne. She has flawless skin! She said, on top of clearing up those breakouts, it would help with the aging I was starting to see. I've been on this for two months now, and wow, the results are amazing! I have zero breakouts, and the fine lines and pores are shrinking. I will leave the house without makeup now. My complexion is glowing and even! My uneven skin and breakouts were a big source of embarrassment for me. I did have peeling, but this was expected. I also had worsening of acne for a few weeks as my skin purged what was already building in the pores. I pushed through, and I am so glad I did. When the dryness flares, I skip a night of Retin-A and use a heavier moisturizer. I also use an oil-free moisturizer every morning."

10 / 10
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53 Report
  • Col...
  • Taken for 6 months to 1 year
  • October 28, 2014

For Acne "I'm a young woman in my early twenties with moderate acne. If you're just starting Retin-A, STICK WITH IT. I started using Retin-A (0.01%) every night in December of 2013. I was very frustrated because my acne became worse for about 2 months. However, I stuck with it and by July 2014, my acne had noticeably decreased. It is now October 2014, and I've been getting compliments on how great my skin looks! For the first time in years, I don't feel like I have to wear liquid foundation to cover up my acne. If you experience flaking, remember that moisturization is key if you're using Retin-A!"

9 / 10
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87 Report

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  • AAG...
  • Taken for 6 months to 1 year
  • April 6, 2014

For Acne "10 MONTH RETIN-A USER: In the beginning of summer 2013, I had the worst breakout ever! My forehead was full of pimples. I couldn't stand it anymore, so I went to see my doctor, and he prescribed me Retin-A. It says to apply it every day overnight after washing your face. So I applied it every night, and the first three weeks my acne was okay. By the second month, I had another mild breakout, but by the third month, it began to calm down again. By the fourth month, the skin around my nose started to peel, and it was very itchy. Because of this, I applied alcohol-free/fragrance-free lotion, and my skin got better. By the sixth month, my acne was under control! I only had a couple of pimples here and there. But the product works wonders! It just takes patience!"

10 / 10
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72 Report
  • san...
  • November 26, 2013

For Acne "I started getting small bumps (not exactly pimples, but should be taken care of immediately, else, it would grow into pimples later) on my forehead and chin areas. It started to spread to my cheeks too. I first started using Retin-A cream. Initially, I had lots of new breakouts, but didn't give up my patience. New breakouts started to fade out on continuous application at only nights after cleansing with Episoft lotion. After a month I started applying Retin-A, my skin texture, pimple marks, and uneven skin tone have improved drastically. The only thing is to use this product only at night after proper cleansing. Initially, this will cause skin peeling and irritation."

8 / 10
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62 Report
  • Car...
  • August 9, 2016

For Acne "I've been using Retin-A for about a week now. If you have oily skin or experience breakouts every morning like me, I would definitely recommend this. I use the .01% dosage recommended by my doctor. They told me I may experience peeling of the skin. My skin has peeled in some spots, but it's not very noticeable. I removed the peeled skin by using baking soda and water (great exfoliant!). Skin varies by person. I've given up on every acne regimen and decided to see my doctor. I swear by this stuff. All my acne scars are fading, and my skin has become significantly smoother."

9 / 10
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49 Report
  • Csc...
  • Taken for less than 1 month
  • December 2, 2018

For Acne "I am in awe of how well this product works! I’ve been on it for 1 week, and my skin is so clear I don’t believe it’s possible! I’ve struggled with acne since I was 12 (I am now a 21-year-old female), and I’ve tried just about everything, including Accutane, but nothing made a big difference. My acne has ranged from moderate to severe. My biggest struggle was the texture-my face was covered in tiny bumps and clogged pores. My derm now put me on .08%. Not only are the pimples gone after a week, but my whiteheads and blackheads have disappeared almost like magic. There is dryness and peeling, which I’m hoping will go away over time, but I’m fine with it because it’s left me with fresh, new skin. I highly, highly recommend this product!"

10 / 10
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33 Report
  • Sea...
  • September 8, 2015

For Acne "My skin was at its worst in my prime adulthood age, so I decided to try Retin-A. I've been using the 0.025% Retin-A gel for 2 months now. I didn't have the initial 'purge' that most talk about, however, I believe it's because I was prescribed the gel vs. cream. Anyways, I overdid it the first week by not following doctor's orders and applying daily right off the bat. Don't, haha. My skin got so dry and flaky that I even burned my chin on my bed while sleeping from my skin being so thin. After that initial scare, I followed my doctor's instructions and gradually worked up to every night use. Best skin in years. Try it, it works! Just don't forget to moisturize a lot. Sunscreen when you go out! Don't overdo it like I did."

10 / 10
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43 Report
  • Ell...
  • January 11, 2020

For Acne "I have jawline acne, dark patches from pigmentation, and uneven skin tone and blemishes from years of cystic acne. I am 44 and Asian. Day 1 to 2, the gel stung like crazy, itchy and warm skin, and redness. Days 3 to 8, peeling skin, inflamed look after washing face. Stinging and itchy. Days 8 and 9, skin is very taut. I needed extra petroleum jelly plus my regular moisturizer, although my regular moisturizer. Days 9 and 10, skin is sensitive, shiny, that I need to use makeup. For peeling skin, I reapply petroleum jelly at the first signs of dryness or flakiness. I used hydrocortisone on itchy spots. On day 10, I stopped using soap to wash my face as it is drying. I use lukewarm water to wash off the petroleum jelly on my face and pat dry my skin. The dryness has reduced today, day 10. I can use the gel without it stinging my skin or being taut and dry. By day 10, my face appears to be clearer in some places, spots are fading. Skin texture is smooth, though tender."

10 / 10
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27 Report
  • kha...
  • Taken for 1 to 6 months
  • April 22, 2015

For Acne "I was suffering from acne due to my sensitive skin and severe summer heat. I tried my teenage acne cream in my late twenties, but I felt it was too mild to work on my much matured skin like now. Then one of my friends, who was a satisfied user of Retin-A, suggested I use Retin-A 0.05%. I started it in the winter to avoid over-sweating and heat of summer. I faced a little flaky skin. The first two weeks my acne broke out a little more than usual, but after that, the acne seemed to decrease. Whenever I felt too dry skin other than the acne-affected area, I used pure Vaseline. Now I am cured and my skin is glowing. I am continuing the use of Retin-A with my regular night cream for its anti-aging properties. And I am quite satisfied with this."

9 / 10
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40 Report
  • Jus...
  • May 25, 2018

For Acne "32-year-old female. I'd been on Acanya (benzoyl peroxide and clindamycin) for about 3 years before it stopped working very suddenly. Like, one day my skin was clear, and the next, I had breakouts on my chin and cheeks again. Anyway, I'd ordered a tube of 0.05% Retin-A online a while ago and used to use it as a spot treatment, which worked for a bit. I think that was too strong for me. Just starting prescribed 0.025% Retin-A and the morning after use on my entire face, my skin was less inflamed. I noticed 2 new pimples surfaced, but they were easily extracted. I use Cetaphil gentle skin cleanser and then a toner + moisturizer in the mornings. Cetaphil cleanser - wait 20 mins - Retin-A - wait 20 mins - and Neutrogena Hydro Boost moisturizer at night. I have noticed some blemishes come to the surface and minor peeling. But my general skin tone looks so much better than when I was using the Acanya, despite those two drawbacks. Will keep using and see what the long-term results look like!"

8 / 10
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13 Report
  • dan...
  • February 10, 2017

For Acne "I've read so many reviews about Retin-A being amazing and working almost immediately, but I have been using this gel for about 7 weeks, and my skin is still so much worse than before I started using it! I broke out in deep, painful acne almost immediately, and it still hasn't gone away. Breakouts all over my face, and my skin is red and very, very noticeably dry and peeling. Hoping it will start to work soon, I'm getting pretty discouraged that it's taking so long! :("

2 / 10
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21 Report
  • Jen...
  • Taken for 1 to 6 months
  • March 5, 2019

For Acne "I started using Retin-A after switching my birth control pills to progesterone only due to severe migraines thought to be caused by estrogen. I am now 23 and never struggled this bad with acne. Before Retin-A, I had a few cystic acne spots on my chin and jawline and small blemishes on my forehead occasionally. After using Retin-A, my face got way worse. The first week, it caused my face to be red, flaky, and burn. This wasn't the typical burning feeling I would get from a topical acne cream. This was a burn that would hurt when I would step outside. It made the cystic acne spots really dry, red, and very sore. I called my dermatologist, and they said those are typical side effects and to mix my moisturizer with the Retin-A. This helped but didn't help enough. I went another 5+ weeks dealing with peeling, flaking, red, irritated, dry, sore skin. I finally decided to stop using it. The next day, my skin was feeling a lot less sore and irritated. This was not the medication for me."

1 / 10
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10 Report
  • Jen...
  • Taken for 1 to 6 months
  • March 5, 2019

For Acne "I started using Retin-A after switching my birth control pills to progesterone only due to severe migraines thought to be caused by estrogen. I am now 23 and never struggled this bad with acne. Before Retin-A, I had a few cystic acne spots on my chin and jawline and small blemishes on my forehead occasionally. After using Retin-A, my face got way worse. The first week, it caused my face to be red, flaky, and burn. This wasn't the typical burning feeling I would get from a topical acne cream. This was a burn that would hurt when I would step outside. It made the cystic acne spots really dry, red, and very sore. I called my dermatologist, and they said those are typical side effects and to mix my moisturizer with the Retin-A. This helped but didn't help enough. I went another 5+ weeks dealing with peeling, flaking, red, irritated, dry, sore skin. I finally decided to stop using it. The next day, my skin was feeling a lot less sore and irritated. This was not the medication for me."

1 / 10
Was this helpful?YesNo
10 Report
  • Jen...
  • Taken for 1 to 6 months
  • March 5, 2019

For Acne "I started using Retin-A after switching my birth control pills to progesterone only due to severe migraines thought to be caused by estrogen. I am now 23 and never struggled this bad with acne. Before Retin-A, I had a few cystic acne spots on my chin and jawline and small blemishes on my forehead occasionally. After using Retin-A, my face got way worse. The first week, it caused my face to be red, flaky, and burn. This wasn't the typical burning feeling I would get from a topical acne cream. This was a burn that would hurt when I would step outside. It made the cystic acne spots really dry, red, and very sore. I called my dermatologist, and they said those are typical side effects and to mix my moisturizer with the Retin-A. This helped but didn't help enough. I went another 5+ weeks dealing with peeling, flaking, red, irritated, dry, sore skin. I finally decided to stop using it. The next day, my skin was feeling a lot less sore and irritated. This was not the medication for me."

1 / 10
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10 Report
  • Aan...
  • Taken for 1 to 6 months
  • November 9, 2018

For Acne "I personally recommend you guys not to use this Retin-A gel for acne. It makes your skin worse and worse with big red boils. I was expecting a change in the initial months, but when I came to a situation where I was not able to leave my house due to the peeling and scars, I was forced to change the doctor. Now I'm not using Retin-A gel for the past month, and things came to normal."

1 / 10
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9 Report
  • T-R...
  • September 15, 2018

For Acne "I am 23 years old and I suffer from severe acne. I started using Retin-A 0.05 a week ago. At first, my face felt moisturized, the pimples became easier to extract. After about 2-3 days, my face started burning and then peeling. I wanted to use a moisturizer along with it, but anything that touched my face made it ache or burn, and when I say anything, I do mean anything... water, fabric, etc. I used it twice a day as advised by my derm. He told me it would get worse before it got better, so I continued applying small amounts on the bigger bumps, but my face hasn't healed, so I have completely stopped using it."

1 / 10
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9 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.