Comparing Quetiapine vs Trazodone

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Quetiapine

Trazodone

Quetiapine is an antipsychotic that calms and sedates, helping to relieve psychotic thoughts and manic and depressive behavior. Sedation, low blood pressure, and weight gain are common side effects... View more

Trazodone is mostly used for its sleep-inducing effects (an off-label indication) rather than as an antidepressant. Only generic forms are available which makes it a lot cheaper than some other... View more

Prescription only

Ratings & Reviews

View all 1875 reviews

View all 1273 reviews

Drug Class

Atypical antipsychotics

Phenylpiperazine antidepressants

Side Effects

Commonly reported side effects include: asthenia, constipation, dizziness, drowsiness, headache, sedated state, increased serum cholesterol, increased serum triglycerides, increased thyroid stimulating hormone level, and xerostomia.

See the full quetiapine side effects document.

Commonly reported side effects include: blurred vision, dizziness, drowsiness, headache, nausea, vomiting, and xerostomia.

See the full trazodone side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	50 each
Dosage	25 mg
Per Unit^*	$1.39
Cost^*	$69.44

View all quetiapine prices

Quantity	7 tablet
Dosage	50 mg
Per Unit^*	$1.68
Cost^*	$11.75

View all trazodone prices

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Generic Availability

Yes (this medicine)

Dosage Form(s) Available

Oral tablet
Oral tablet, extended release

Oral tablet

Brand Names

Seroquel, Seroquel XR Desyrel, Desyrel Dividose

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

6 hours

7.5 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 660 drugs are known to interact with quetiapine:

125 major drug interactions (441 brand and generic names)
528 moderate drug interactions (2110 brand and generic names)
7 minor drug interactions (32 brand and generic names)

A total of 593 drugs are known to interact with trazodone:

125 major drug interactions (467 brand and generic names)
453 moderate drug interactions (1723 brand and generic names)
15 minor drug interactions (73 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Alcohol can increase the nervous system side effects of traZODone such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

September 26, 1997

December 24, 1981

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer