Paxil Alternatives Compared
| Paxil | Trintellix | Rexulti |
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| Paxil (paroxetine) | Trintellix (vortioxetine) | Rexulti (brexpiprazole) |
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Prescription only
Paxil may be used for the treatment of depression, anxiety, or posttraumatic stress disorder. It should be tapered off slowly on discontinuation. Prescribed for Anxiety and Stress, Anxiety... View more |
Prescription only
Trintellix may be used to treat depression in adults. It is different from other antidepressants currently on the market because it directly affects serotonin receptors as well as inhibits serotonin... View more |
Prescription only
Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression. Most people experience some improvement in their symptoms within 1 to 2 weeks of starting... View more |
Related suggestions Depression
Popular comparisons
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| More about Paxil (paroxetine) | More about Trintellix (vortioxetine) | More about Rexulti (brexpiprazole) | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
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No lower-cost generic available |
No lower-cost generic available |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Paxil has an average rating of 7.0 out of 10 from a total of 926 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 21% reported a negative effect. |
Trintellix has an average rating of 5.9 out of 10 from a total of 1045 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 34% reported a negative effect. |
Rexulti has an average rating of 6.4 out of 10 from a total of 401 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 28% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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Common side effects include:
See also: Paxil side effects in more detail. |
Common side effects include:
See also: Trintellix side effects in more detail. |
See also: Rexulti side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Paxil prices and generic prices |
View all Trintellix prices |
View all Rexulti prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Other paroxetine brands include: Brisdelle, Paxil CR, Pexeva |
N/A |
N/A |
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| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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21 hours |
66 hours |
91 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category D
Positive evidence of risk
Excluding Brisdelle
Category X
Not for use in pregnancy
Brisdelle See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 487 drugs are known to interact with Paxil:
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A total of 338 drugs are known to interact with Trintellix:
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A total of 539 drugs are known to interact with Rexulti:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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December 29, 1992 |
September 30, 2013 |
July 10, 2015 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
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N/A |
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| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.