Oxycodone Alternatives Compared
| Oxycodone | Tramadol | Methadone |
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| Oxycodone | Tramadol | Methadone |
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Prescription only
Oxycodone is a potent pain-relieving medicine that should be reserved for mainly cancer-related pain. It carries a high potential for addiction and common side effects include sedation and... View more |
Prescription only
Tramadol is a strong pain relief medicine effective for both general and nerve-related pain. Tramadol can cause dependence and use may be limited by side effects such as nausea and... View more |
Prescription only
Methadone is a potent opioid analgesic that may be used to relieve severe pain unresponsive to other strong pain relievers; however, it is more commonly used to treat opioid addiction. There is a... View more |
Related suggestions Chronic Pain
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| More about Oxycodone | More about Tramadol | More about Methadone | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Oxycodone has an average rating of 7.0 out of 10 from a total of 1068 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 24% reported a negative effect. |
Tramadol has an average rating of 6.8 out of 10 from a total of 1729 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 25% reported a negative effect. |
Methadone has an average rating of 8.7 out of 10 from a total of 563 ratings on Drugs.com. 85% of reviewers reported a positive effect, while 5% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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Commonly reported side effects include:
See also: oxycodone side effects in more detail. |
Commonly reported side effects include:
See also: tramadol side effects in more detail. |
See also: methadone side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all oxycodone prices |
View all tramadol prices |
View all methadone prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Dazidox, Endocodone, ETH-Oxydose, Oxaydo, OxyContin, Oxydose, Oxyfast, Roxicodone, RoxyBond, Xtampza ER View more | ConZip, Qdolo, Tramadol Hydrochloride ER, Ultram | Methadone Diskets, Methadose, Methadose Sugar-Free | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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5.6 hours |
5.2 hours |
30 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
Some potential for abuse
Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category N
Not classified
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 551 drugs are known to interact with oxycodone:
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A total of 640 drugs are known to interact with tramadol:
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A total of 680 drugs are known to interact with methadone:
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| First Approval Date | ||||||||||||||||||||||||||
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October 26, 1998 |
March 03, 1995 |
August 13, 1947 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
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| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.