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Oxycodone Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Oxycodone Remove Oxycodone from your drug comparison Tramadol Remove Tramadol from your drug comparison Methadone Remove Methadone from your drug comparison
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Oxycodone Remove Oxycodone from your drug comparison Tramadol Remove Tramadol from your drug comparison Methadone Remove Methadone from your drug comparison

Oxycodone is a potent pain-relieving medicine that should be reserved for mainly cancer-related pain. It carries a high potential for addiction and common side effects include sedation and... View more

Tramadol is a strong pain relief medicine effective for both general and nerve-related pain. Tramadol can cause dependence and use may be limited by side effects such as nausea and... View more

Methadone is a potent opioid analgesic that may be used to relieve severe pain unresponsive to other strong pain relievers; however, it is more commonly used to treat opioid addiction. There is a... View more

Prescription only

Prescription only

Prescription only

Ratings & Reviews

View all 987 reviews

View all 1606 reviews

View all 547 reviews

Drug Class

Side Effects

Commonly reported side effects include: constipation, drowsiness, nausea, pruritus, vomiting.

See the full oxycodone side effects document.

Commonly reported side effects include: pruritus, agitation, anxiety, constipation, diarrhea, hallucination, nausea, tremor, vomiting, diaphoresis.

See the full tramadol side effects document.

See the full methadone side effects document.

Pricing and Coupons

* Prices are without insurance
Quantity 100 each
Dosage 5 mg
Per Unit* $0.26
Cost* $26.23

View all oxycodone prices

Quantity 9 tablet
Dosage 50 mg
Per Unit* $1.30
Cost* $11.74

View all tramadol prices

Quantity 100 each
Dosage 10 mg
Per Unit* $0.21
Cost* $21.02

View all methadone prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Generic Availability

Yes (this medicine)

Yes (this medicine)

Yes (this medicine)

Dosage Form(s) Available
  • Oral capsule
  • Oral concentrate
  • Oral solution
  • Oral tablet
  • Oral tablet, extended release
  • Oral capsule, extended release
  • Oral tablet
  • Oral tablet, extended release
  • Compounding powder
  • Injectable solution
  • Oral concentrate
  • Oral solution
  • Oral tablet
  • Oral tablet, dispersible

Brand Names
Dazidox, Endocodone, ETH-Oxydose, Oxaydo, OxyContin, Oxydose, Oxyfast, Roxicodone, Xtampza ER View more ConZip, Qdolo, Tramadol Hydrochloride ER, Ultram Methadone Diskets, Methadose, Methadose Sugar-Free

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

5.6 hours

5.2 hours

30 hours

CSA Schedule**

View glossary of terms.
2
High potential for abuse

Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
4
Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
2
High potential for abuse

Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.

Pregnancy Category
N
Category N Not classified

See the full Pregnancy Warnings document.
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

FDA Alerts

FDA Alerts (2)

FDA Alerts (4)

FDA Alerts (5)

Drug Interactions

A total of 532 drugs are known to interact with oxycodone:

  • 200 major drug interactions (723 brand and generic names)
  • 331 moderate drug interactions (1341 brand and generic names)
  • 1 minor drug interactions (3 brand and generic names)

A total of 542 drugs are known to interact with tramadol:

  • 293 major drug interactions (1036 brand and generic names)
  • 246 moderate drug interactions (1107 brand and generic names)
  • 3 minor drug interactions (14 brand and generic names)

A total of 661 drugs are known to interact with methadone:

  • 307 major drug interactions (1054 brand and generic names)
  • 344 moderate drug interactions (1515 brand and generic names)
  • 10 minor drug interactions (28 brand and generic names)

Alcohol/Food/Lifestyle Interactions
  • Do not use alcohol or medications that contain alcohol while you are receiving treatment with... View more
  • Alcohol can increase the nervous system side effects of traMADol such as dizziness, drowsiness, and... View more
  • Grapefruit juice can increase the blood levels and effects of methadone. If you regularly consume... View more
  • Do not use alcohol or medications that contain alcohol while you are receiving treatment with... View more

Disease Interactions

First Approval Date

October 26, 1998

March 03, 1995

August 13, 1947

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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