Skip to Content

Oxycodone Drug Interactions

A total of 951 drugs are known to interact with oxycodone.

  • 340 major drug interactions
  • 609 moderate drug interactions
  • 2 minor drug interactions

Show all medications in the database that may interact with oxycodone.

Check for interactions with oxycodone

Type in a drug name and select a drug from the list.

Common medications checked in combination with oxycodone

  • acetaminophen (Tylenol, Paracetamol, Panadol, Mapap, Tylenol Extra Strength, Tylenol Arthritis Pain, Perfalgan, Ofirmev, Arthritis Pain Relief, Doliprane, Dafalgan, Efferalgan, Altenol, Children's Tylenol, Cipla Genpharm Paracetamol, Feverall, Tempra, Paracetamol Almus, Paracetamol Teva, Infant's Tylenol, Cetafen, Panadol Osteo, Promax, Lemsip Original, Panadol Soluble, Aceta, Buckley's Complete, Paracetamol Ranbaxy, Atasol, Tactinal, Mapap Arthritis Pain, Panadol Gel Tabs, Tylophen, Genapap, Pain Clear Paracetamol, Setamol, Tylenol 8 Hour, Capital Chemist Paracetamol, Lemsip Max, Chemists Own Paracetamol Pain & Fever 1 Month to 2 Years, Panadol Childrens, Panamol, Taminol, Pharbetol, Anacin Aspirin Free, Efferalgan Pediatrique, Paracetamol Biogaran, Paracetamol Ivax, Actamin, BF-Paradac, Paracetamol Sandoz, Q-Pap, Acetaminophen-odan, Calpol Fastmelts, Aminofen, Hedex, Miradol, Panadol ActiFast, Paralgin, Febridol, Parmol, Lemsip Childrens Cold & Flu, Orajel Maximum Strength Toothache, Paraspen, RP Scherer Paracetamol, Terry White Chemists Paracetamol, Pharmacist Advice Paracetamol, Terry White Chemists Paracetamol Colourfree Children 5-12 Years, Paracare, Tylenol Childrens Paracetamol, Conney Aspirin-Free, Priceline Paracetamol, Panadol Gel Caps, Pacimol Caplets, Pharmore Paracetamol, Basics Paracetamol, Sigma Pain Relief, Paraspen Drops, Panadol Colourfree Drops, Pharmacist Paracetamol Infant Drops, Pharmacist Paracetamol Infant Drops Colour Free, Bi-Lo Paracetamol, Pain-Eze Paracetamol Infant Drops Colour Free, Pharmaction Paracetamol, Biochemie Paracetamol, Healthsense Pain Relief Drops Children 1 Month to 2 Years, Black And Gold Paraceatmol, Pharmacist Advice Paracetamol Infant Drops, Black and Gold Paracetamol, Hexal Comfarol, Blooms the Chemist Paracetamol, Panadol Extend, Abenol, Paracetamol Soluble, Vitapap, Bristol Pharma Paracetamol, Sigma Paracetamol, Actimol Infant, ConRx Extra Strength, PediaCare Infants' Acetaminophen Fever Reducer/Pain Reliever, PediaCare Children's Acetaminophen Fever Reducer/Pain Reliever, Pharmacy Health Paracetamol Colour Free Childrens, PediaCare Smooth Melts Acetaminophen Fever Reducer/Pain Reliever, Pharmacy Health Paracetamol Colour Free Infants and Childrens Drops 1 Month-4 Years, Mapap Children's, Lemsip Cold and Flu Liquid Capsule, Children's Silapap, Febrol Solution, Pharmacy Health Own Name Paracetamol for Children, Febridol Infant Drops, Accidental Rapatabs, Chem Mart Chemadol Children 1 to 5 Years, Chem Mart Chemadol Colourfree, Chem Mart Chemadol Colourfree Children 5-12 Years, Chemists Own Chiildrens Paracetamol 5-12 Years, Lemsip Headcold, Chemists Own Childrens Paracetamol 1-5 Years, Chemists Own Paracetamol, Chemists Own Paracetamol Capseals, Chemists Own Paracetamol Pain & Fever 1 to 5 Years, Chemists Own Paracetamol Pain and Fever 5 to 12 Years, A-Pak Laboratories Paediatric Analgesic Paracetamol, Chemplus Paracetamol, Chemworld Colourfree Childrens Paracetamol Double Strength 5-12 Years, Chemworld Colourfree Childrens Paracetamol Junior 1-5 Years, Chemworld Paracetamol, Chemworld Paracetamol Infant Colour Free, HyVee Health 8 Hour Pain Relief, Bydol, Chem Mart Chemadol, Leader 8 Hour Pain Reliever, Children's ElixSure, Little Fevers, Mapap Rapid Release Gelcaps, Benylin Sore Throat, Fawns & McAllan Paracetamol, Zee Unaspirin ES, Chem Mart Chemadol Colourfree Childrens 1-5 Years, Midol Long Lasting Relief, Childrens Panadol 1 - 5 Years Colourfree, Childrens Panadol 1 - 5 Years, Childrens Panadol 5 - 12 Years Colourfree, Childrens Panadol 5 - 12 Years, Equaline Pain Relief, Help I Have A Headache, Febridol Clear Effervescent, Herron Paracetamol Tabsules, Panadol Rapid Handipak, Paralgin Paracetamol Tabsules, Pharmacist Childrens Paracetamol Colourfree 1-5 Years, Pharmacist Childrens Paracetamol Colourfree 5-12 Years, Pharmacy Health Colour Free Childrens Paracetamol, Gold Cross Paracetamol, Tylenol Cold Sore Throat, Alpha First Aid Supplies Paracetamol, Guardian Childrens Paracetamol 5-12 Years, Guardian Paracetamol, Guardian Paracetamol Tabsules, Acephen, Rex Paracetamol, Topcare Arthritis Pain Relief, Accidental First Aid Supplies Paracetamol, Panadol Jr, Flu Strength Hot Lemon Powders, Paineze Paracetamol, Health Care Chemist Paracetamol Infant Drops Colour Free, Genebs, Herron Gold Paracetamol Tabsules, Tylenol Regular Strength, Herron Paracetamol, Tempra 2, Tempol, Herron Paracetamol Capseals, Tempra 3, Herron Paracetamol Capseals Handy Pack, Herron Paracetamol Handy Pack, Apra, Q-Nol, Claradol, Conacetol, Dolono, Doliprane Adultes, Coles Paracetamol, Genapap Extra Strength, Doliprane Sans Sucre, Dolitabs, Home Brand Paracetamol, Q-Pap Extra Strength, Dolko, ICN Paracetamol, Redutemp, Dolko Enfants, Dolotec, Vicks Formula 44 Custom Care Body Aches, James Dean Pharmacy Paracetamol, Pain-Eze, Uniserts, Efferalganodis, Silapap Childrens, Expandox, Dolono Infant, Geluprane, Paracetamol Arrow, Ed-APAP, Paracetamol EG, St. Joseph Aspirin-Free, Country Chemists Paracetamol, Paracetamol Merck, Liquiprin, Paracetamol Qualimed, Adprin B, Paracetamol RPG, DG Health Pain Reliever, Tempra Quicklets, Paracetamol Sandoz Conseil, Tycolene, Lloydspharmacy Paracetamol Six Plus, Paracetamol Winthrop, Triaminic Fever Reducer Pain Reliever, Lloydspharmacy Paracetamol Infant, Paracetamol Zydus, Triaminic Infant Drops, Atasol Forte, Paralyoc, Tylenol Cool Caplet Extra Strength, Perfalgan Nourrissons Et Enfants, Mapap Rapid Tabs, Jr. Tylenol, Mapap Extra Strength Rapid Burst, Elixsure Fever/Pain, Infadrops, Disprol Soluble Paracetamol, Calpol Infant, Disprol Paracetamol, Galpamol, Paldesic, Calpol Paediatric, Medinol Paediatric, Medinol Under 6, Alvedon, Infantaire Drops, Lemsip Pharmacy Non-Decongestant Formula, Calpol Six Plus, Masophen, Medinol Over 6, Nortemp Children's, Paracets, Anadin Paracetamol, UN-Aspirin Extra Strength, Mandanol, Valorin, Actimol Children's, Dakota Paracetamol, Umphamol, Remedol, Panamax, Panamax 240, Parahexal, Mid West Products Numol Paracetamol, Silapap Infants, Cuprofen for Children, Mapap Infant Drops, Mandanol Infant, Cetafen Extra, Mandanol 6+, Fennings Childrens Cooling, Duatrol SR, Aldi Hedanol Paracetamol, Under Ten Care Infant, Alphapharm Paracetamol, Amadol Paracetamol, No Frills Paracetamol, Tylenol Sore Throat Daytime, Nova Paracetamol, Mapap Meltaway, Numark Paracetamol, Amcal Childrens Paracetamol 1-5 Years, Nyal Paracetamol, Medi-Tabs, Amcal Childrens Paracetamol 5-12 Years, Amcal Paracetamol Pain Relief, Ordov Febrigesic Paracetamol, Topcare 8 Hour Pain Relief, Amcal Paracetamol Infant Drops 1 Month to 2 Years, Pain-Eze Paracetamol Infant Drops, Febridol Syrup for Children, Amcal Paracetamol Tabsules, Pharmacist Advice Colourfree Childrens Paracetamol Double Strength, Guardian Childrens Paracetamol, Pharmacist Formula Paracetamol, Pharmacist Formula Infants, RP Scherer Paracetamol Liquid-Filled Capsules, Savings Paracetamol, Signature Range Paracetamol, Dymadon, Soul Pattinson Childrens Paracetamol Elixir, Soul Pattinson Colour Free Paracetamol 1-5 Years, Soul Pattinson Colour Free Paracetamol Drops, Soul Pattinson Colourfree Childrens Paracetamol, API Healthcare Coloufree Childrens Paracetamol, Soul Pattinson Paracetamol, API Healthcare Colourfree Childrens Paracetamol Double Strength, Soul Pattinson Paracetamol Clear Effervescent, Panadol Mini Caps, API Healthcare Paracetamol, Pharmacy Health Paracetamol, Terry White Chemists Colour Free Paracetamol 1-5 Years, Pharmacist Paracetamol, Terry White Chemists Colour Free Paracetamol Infant Drops)
  • Adderall (amphetamine / dextroamphetamine)
  • Advil (ibuprofen)
  • Aleve (naproxen)
  • Ambien (zolpidem)
  • aspirin (Aspir 81, Ecotrin, Acetylsalicylic Acid, Aspirin Low Strength, Bayer Aspirin, Aspir-Low, Ascriptin, Bufferin, Ecotrin Adult Low Strength, Arthritis Pain, Fasprin, Halfprin, Aspiritab, Easprin, Aspergum, Durlaza, St. Joseph 81 mg Chewable Aspirin, Empirin, Buffered Aspirin, Ecotrin Maximum Strength, Ascriptin Enteric, Migralex, Aspi-Cor, Aspirtab, Low Dose ASA, Bufferin Extra Strength, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Bayer Aspirin Regimen, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Bufferin Low Dose, Medi-Seltzer, Sloprin, ZORprin, Bayer Children's Aspirin, Bayer Aspirin Extra Strength Plus, Buffex, Entercote, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Therapy Bayer, St. Joseph Aspirin, Stanback Analgesic, Norwich Aspirin, Acuprin 81, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Aspirin Lite Coat, Heartline, Bayer Advanced Aspirin, Buffasal)
  • Cymbalta (duloxetine)
  • Fentanyl Transdermal System (fentanyl)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Flexeril (cyclobenzaprine)
  • hydrocodone (Hysingla ER, Zohydro ER, Vantrela ER)
  • ibuprofen (Advil, Motrin, IBU, Children's Motrin, Advil Liqui-Gels, Proprinal, IBU-200, Motrin IB, Advil Migraine, Ibu-8, Motrin Childrens, Caldolor, Ibuprofen PMR, Nuprin, Childrens Ibuprofen Berry, Motrin Migraine Pain, Addaprin, NeoProfen, Advil Infant's Concentrated Drops, Ibu-Tab, Rufen, Genpril, Motrin Infant Drops, Haltran, Menadol, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Advil Children's, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • Lasix (furosemide)
  • Lipitor (atorvastatin)
  • Lyrica (pregabalin)
  • meloxicam (Mobic, Vivlodex, Qmiiz ODT)
  • methadone (Methadose, Dolophine, Methadone Diskets, Methadose Sugar-Free)
  • MiraLax (polyethylene glycol 3350)
  • Morphine Sulfate ER (morphine)
  • Motrin (ibuprofen)
  • Mucinex D (guaifenesin / pseudoephedrine)
  • Neurontin (gabapentin)
  • Nexium (esomeprazole)
  • OxyContin (oxycodone)
  • prednisone (Deltasone, Sterapred, Rayos, Sterapred DS, Prednicot, Orasone, Meticorten, Liquid Pred, Prednicen-M)
  • Suboxone (buprenorphine / naloxone)
  • Synthroid (levothyroxine)
  • Tylenol (acetaminophen)
  • Valium (diazepam)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Wellbutrin (bupropion)
  • wine
  • Xanax (alprazolam)
  • Zofran (ondansetron)

Oxycodone alcohol/food interactions

There is 1 alcohol/food interaction with oxycodone

Oxycodone disease interactions

There are 17 disease interactions with oxycodone which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide