Orilissa Alternatives Compared
| Orilissa | Norethindrone | Lupron Depot |
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| Orilissa (elagolix) | Norethindrone | Lupron Depot (leuprolide) |
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Prescription only
Prescribed for Endometriosis. Orilissa may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Abnormal Uterine Bleeding, Endometriosis, Amenorrhea, Birth Control, Gender Affirming Hormone Therapy . norethindrone may also be used for purposes not listed in this medication guide. |
Prescription only
Lupron Depot is a hormone deprivation treatment that may be used for the palliative care of advanced prostate cancer. The main side effects are hot flashes and general pain and it may cause... View more |
Related suggestions Endometriosis
Popular comparisons
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| More about Orilissa (elagolix) | More about Norethindrone | More about Lupron Depot (leuprolide) | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
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No lower-cost generic available |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Orilissa has an average rating of 5.3 out of 10 from a total of 126 ratings on Drugs.com. 40% of reviewers reported a positive effect, while 40% reported a negative effect. |
Norethindrone has an average rating of 4.9 out of 10 from a total of 1552 ratings on Drugs.com. 33% of reviewers reported a positive effect, while 45% reported a negative effect. |
Lupron Depot has an average rating of 5.8 out of 10 from a total of 215 ratings on Drugs.com. 44% of reviewers reported a positive effect, while 34% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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See also: Orilissa side effects in more detail. |
See also: norethindrone side effects in more detail. |
See also: Lupron Depot side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Orilissa prices |
View all norethindrone prices |
View all Lupron Depot prices and generic prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
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N/A |
Affodel, Camila, Deblitane, Emzahh, Errin, Heather, Incassia, Jencycla, Lyleq, Lyza, Nor-QD, Norlyda, Norlyroc, Sharobel, Tulana View more | Other leuprolide brands include: Camcevi, Eligard, Fensolvi, Lupron, Lupron Depot-PED | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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6 hours |
10 hours |
4.25 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 349 drugs are known to interact with Orilissa:
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A total of 247 drugs are known to interact with norethindrone:
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A total of 275 drugs are known to interact with Lupron Depot:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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July 23, 2018 |
April 21, 1982 |
January 26, 1989 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.