Skip to main content

Gonadotropin-releasing hormone antagonists

What are Gonadotropin-releasing hormone antagonists?

*Gonadotropin-releasing hormone (GnRH) antagonists are synthetic analogs of gonadotropin-releasing hormone, which is produced by the hypothalamus and controls the secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary. Gonadotropin-releasing hormone antagonists bind to gonadotropin-releasing hormone receptors and decrease the effect of gonadotropin-releasing hormone.

In men, gonadotropin-releasing hormone antagonists inhibit the release of luteinizing hormone, and consequently less testosterone is produced. Testosterone stimulates the growth of many forms of prostate cancer. Gonadotropin-releasing hormone antagonists are used to treat prostate cancer as by reducing the levels of testosterone the size of prostate cancer is reduced.

Gonadotropin-releasing hormone antagonists are used to treat women undergoing fertility treatment. It prevents early release of luteinizing hormone (LH) and premature ovulation in women being administered follicle-stimulating hormone (FSH) when preparing for in-vitro fertilization.

List of Gonadotropin-releasing hormone antagonists

View by  Generic | Brand
Drug Name Avg. Rating Reviews
elagolix systemic (Pro)
Brand name: Orilissa
5.4
 129 reviews
relugolix systemic (Pro)
Brand name: Orgovyx
7.8
 22 reviews
degarelix systemic (Pro)
Brand name: Firmagon
8.8
 14 reviews
ganirelix systemic (Pro)
Brand name: Fyremadel 		No reviews
cetrorelix systemic (Pro)
Brand name: Cetrotide 		No reviews
For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).

See also

Medical conditions treated or associated with gonadotropin-releasing hormone antagonists:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer