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Generic name: Elagolix
Brand name: Orilissa
Dosage form: oral tablet
Drug class: Gonadotropin-releasing hormone antagonists

Medically reviewed by Philip Thornton, DipPharm. Last updated on Apr 4, 2023.

What is elagolix?

Elagolix belongs to a class of drugs called gonadotropin-releasing hormone (GnRH) receptor antagonist. It is an oral tablet used to help treat pain caused by endometriosis.

Endometriosis is a condition where tissue that should line the uterus or womb, grows outside of the uterus forming lesions. It affects about 1 in 10 women of reproductive age.

During your menstrual cycle these lesions grow in response to rising levels of a hormone called estrogen, then they break down and shed during your period. This can cause pain throughout your cycle.

Elagolix helps to reduce the pain you experience by reducing the amount of estrogen you produce that encourages the lesions to grow. Elagolix works by binding to GnRH receptors in the pituitary gland, which suppresses luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and leads to a decrease in estrogen.

What is elagolix used for?

Elagolix is a prescription medicine used to treat moderate to severe pain associated with endometriosis. It is not known if elagolix is safe and effective in children.

Important information

Elagolix may cause serious side effects, including:

Who should not take elagolix?

Do not take elagolix if you:

What should I tell my doctor before taking elagolix?

Before you take elagolix, tell your healthcare provider about all of your medical conditions, including if you:

How should I take elagolix?

What happens if I miss a dose?

If you miss a dose of elagolix:

What happens if I overdose?

If you take too much elagolix, call your healthcare provider or go to the nearest hospital emergency room right away.

Dosing information

Two dosing regimens are available:

What are the side effects of elagolix?

Elagolix can cause serious side effects including:

You or your caregiver should pay attention to any changes, especially sudden changes in your mood, behaviors, thoughts, or feelings.

The most common side effects of elagolix include: hot flashes and night sweats, headache, nausea, difficulty sleeping, absence of periods, anxiety, joint pain, depression and mood changes.

These are not all the possible side effects of elagolix. Call your doctor for medical advice about side effects.

You may report side effects to FDA at 1-800-FDA-1088.


Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you take:

Know the medicines you take. Keep a list of your medicines with you to show to your healthcare provider and pharmacist when you get a new medicine.

Pregnancy and breastfeeding


What are the ingredients in elagolix?

Active ingredient: elagolix

Inactive ingredients:

150 mg tablets: mannitol, sodium carbonate monohydrate, pregelatinized starch, povidone, magnesium stearate, polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, and carmine high tint.

Inactive ingredients 200 mg tablets: mannitol, sodium carbonate monohydrate, pregelatinized starch, povidone, magnesium stearate, polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, and iron oxide red.

Elagolix is manufactured under the brandname Orilissa by AbbVie Inc. North Chicago, IL 60064

Popular FAQ

Elagolix (brand name: Orilissa) is used to treat moderate to severe endometriosis (endo) pain. Endometriosis is a chronic disease for which there is currently no cure. Elagolix for endometriosis pain was approved by the FDA in June 2018. It works by blocking the effects of GnRH (gonadotropin-releasing hormone) and reducing estrogen production, which may help to lower your endo pain.

Elagolix can be used to treat uterine fibroids when it is given as the brand Oriahnn which combines elagolix with estradiol and norethindrone acetate. Elagolix, as the brand Orlissa, is only approved to treat endometriosis-associated pain.

Elagolix is approved to help reduce endometriosis-associated pain, and research has also shown that it can reduce heavy menstrual bleeding in women with fibroids although this is not without side effects. Women with uterine fibroids were treated with Elagolix in addition to hormonal “Add-back” therapy for 6 months. 68.5% in one study and 76.5% in the other reported at least a 50% reduction in menstrual blood loss from the start of the study to the final month and a menstrual blood loss of less than 80mL by the final month of the study. Using Elagolix to reduce heavy menstrual bleeding is an unapproved use for the drug. Continue reading

Non-hormonal birth control methods (contraceptives) should be used during treatment with Orilissa (elagolix) and for one week after to prevent pregnancy. Non-hormonal birth control methods include condoms and spermicides. Continue reading

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.