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What types of birth control work with Orilissa?

Medically reviewed by Last updated on Aug 13, 2020.

Official Answer


You should use reliable methods of birth control that DO NOT contain hormones (for example, condoms and spermicide) while taking Orilissa, and for one week after you stop taking Orilissa.

Birth control pills that contain estrogen may lower the effectiveness of Orilissa in treating your endometriosis pain. It is not known how well Orilissa will work while you are using progestin-only birth control such as injections or implants.

Orilissa (elagolix) is a treatment for the pain associated with endometriosis but it does not prevent pregnancy. Talk to your doctor or other health care provider about what type of birth control you should use during treatment with Orilissa. Your health care provider may need you to change your birth control method.

Exposure to Orilissa early in pregnancy may increase the risk of early pregnancy loss. Do not use Orilissa if you are or may be pregnant. If you think you are pregnant, stop taking Orilissa right away and call your health care provider.

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