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Can Kyleena cause weight gain?

Medically reviewed by Carmen Fookes, BPharm. Last updated on Sep 22, 2020.

Official Answer

by Drugs.com

Yes, Kyleena can cause weight gain in some women although this is not listed as a common side effect of Kyleena. Weight gain associated with Kyleena is most likely due to water retention caused by the progestin contained in Kyleena, rather than an increase in body fat percentage. In most women, the bloating should subside within a few months.

How does Kyleena cause weight gain?

Kyleena is a T-shaped plastic contraceptive device that is inserted into the uterus and which contains the hormone progestin which is thought to increase plasma volume by causing increased protein retention in the vascular space as well as an overall expansion of extracellular fluid.

This causes fluid retention which in turn can lead to bloating.

How can you treat Kyleena-associated weight gain?

In most women, the bloating caused by Kyleena will subside as a woman’s body gets used to the progestin in the contraceptive device. In addition, women are more likely to gain weight during their reproductive years, whether they have an IUD or not.

Other recent lifestyle changes should also be considered as a factor for weight gain, such as an increase in food intake, a decrease in exercise, stress, or other medications. All women should ensure they eat a healthy balanced diet, partake in regular exercise, and stay hydrated with lots of water.

If the weight gain is significant or worrisome and lifestyle changes have not made a difference, then contact your doctor for further advice.

What are the most common side effects with Kyleena?

The most common side effects reported in clinical trials with Kyleena include:

  • Vulvovaginitis (irritation and inflammation of the vulva and vaginal area): 24.3%
  • Ovarian cysts: 22.2%
  • Acne: 14.1%
  • Abdominal pain: 13.3%
  • Headache: 12.9%
  • Pelvic pain: 8.2%
  • Dysmenorrhea (pain during menstruation): 8%
  • Increased bleeding: 7.9%
  • Breast pain: 7.1%
  • Nausea: 4.7%
  • Genital discharge: 4.5%
  • Depression: 4.4%
  • Breast discomfort: 3.5%
  • Device expulsion: 3.5%
  • Migraine: 3.3%
  • Uterine spasm: 2.4%
  • Seborrhea (excessive discharge of sebum): 1.8%
  • Upper genital tract infections: 1.5%
  • Alopecia: 1%

Serious adverse events that occur in less than 1% of people include ectopic pregnancy, pelvic inflammatory disease, spontaneous abortion, and uterine perforation.


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