Orilissa Interactions
There are 374 drugs known to interact with Orilissa (elagolix), along with 3 disease interactions. Of the total drug interactions, 52 are major, 304 are moderate, and 18 are minor.
- View all 374 medications that may interact with Orilissa
- View Orilissa disease interactions (3)
Most frequently checked interactions
View interaction reports for Orilissa (elagolix) and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- albuterol
- Benadryl (diphenhydramine)
- bupropion
- buspirone
- cetirizine
- cyclobenzaprine
- duloxetine
- gabapentin
- hydroxyzine
- ibuprofen
- lamotrigine
- Lyrica (pregabalin)
- melatonin
- meloxicam
- metformin
- norethindrone
- omeprazole
- pantoprazole
- prednisone
- propranolol
- sertraline
- spironolactone
- tizanidine
- trazodone
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Vyvanse (lisdexamfetamine)
- Zyrtec (cetirizine)
Orilissa disease interactions
There are 3 disease interactions with Orilissa (elagolix) which include:
Report options
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- Dosage information
- During pregnancy
- FDA approval history
- Drug class: gonadotropin-releasing hormone antagonists
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
