Lupron Depot and Hot Flashes: What Users Say

• mrm...
• August 2, 2016

For Uterine Fibroids "I had a fibroid that had grown into my uterine cavity and it caused heavy bleeding, large blood clots, and discomfort. I had surgery scheduled in June of 2016 and was given a Lupron injection in March of 2016 to shrink the fibroid to make surgery easier. I had read terrible reviews and was scared of the side effects. Overall my experience was very positive. I had minor side effects such as hot flashes and migraines. I am in my mid-twenties and very active, which I believe helped. No weight gain or hair loss. I felt great throughout the 3 months and actually felt more mentally and hormonally balanced than ever before...I'm actually kind of upset it has worn off! Don't be afraid of this drug, it worked wonders for me!"

• Sar...
• January 2, 2016

For Endometriosis "Don't let the online reviews cheat you out of a better life! I actually delayed getting Lupron by a year because I was so scared by the online reviews and reports of adverse reactions/symptoms. However, my experience was wonderful. My doctor put me on the ad-back and I did have a few hot flashes initially, but I would take those 1,000x over the pain my endometriosis caused me. I also took calcium to offset any bone density loss. Please, please, please work with your doctor to decide if Lupron is right for you. I did it and now I am on my way to restoring my quality of life."

• Kri...
• May 15, 2015

For Uterine Fibroids "I've been on Lupron since March 2015. Just had my 2nd shot. I have to tell you it's taken 100% of my nagging back pain and cramps away. I even lost 12 pounds after the first shot. It started to wear off towards the end so I took the shot 2 weeks early. I had surgery on May 12th to remove a huge polyp and 2 fibroid tumors - all benign. I'm having hot flashes, some headaches, some joint pain and that's about it. These symptoms are worth the trade from previous symptoms. I only hope my doctor gives me a hysterectomy soon. She feels Lupron will shrink the fibroids outside my uterus. I'm almost 50 so she says I should hold off on the hysterectomy. I want all this done with. Good luck to all of you."

• Oac...
• February 3, 2014

For Prostate Cancer "Started treatment 12/2011 ended 12/2013. The PSA went down as expected for the purpose of treatment, now waiting for side effects to end, which have been: loss of libido, hot flashes especially at night or after a meal, some sweating, loss of body hair, loss of muscle mass, joint and bone pain, tiredness, difficulty to start almost any quest, weight gain, chest/man breast augmentation. Have been taking vitamin D plus calcium, glucosamine, started an exercise program that has helped with muscle buildup, and also helps with better mood, by prescription have taken 3 applications of calcium to the vein. Have had excellent support from wife, have trust my Doctors and first of all God my father."

• Lup...
• Taken for 1 to 6 months
• February 19, 2019

For Uterine Fibroids "I wanted to write a review for other women who are thinking about getting this injection. I read a lot of horror stories online, so I was pretty nervous. I got the 3-month injection to try and shrink my large fibroids. The upshot is, it wasn't that bad, but my fibroids didn't shrink; however, it stopped my periods. Preventing the excessive bleeding is good for health prior to a hysterectomy. But it's expensive, and insurance will make you jump through bureaucratic hoops to get it. After getting the shot, I felt kind of weird. Then I had one last awful period blowout a few days later. Since then, no periods. Menopause symptoms included hot flashes, brain fog, mild acne, some moodiness, and irritability. However, I think a lot of this can be worked around with good nutrition, exercise, breathable clothing, and meditation."

• mik...
• September 17, 2009

For Prostate Cancer "I've been on Lupron (after prostate surgery) for a period of 7-1/2 years. I am also on 50mg Casodex. The side effects are minor (hot sweats, decreased energy). Injection sites were moved after 6 years from buttocks to shoulders due to lower back pain. I hope this gives hope to patients about to begin this regimen."

• Lin...
• Taken for less than 1 month
• September 30, 2018

For Endometriosis "I’m a 24-year-old female who’s suffered from terrible endometriosis pain; my periods left me crumpled up on the ground, moaning in pain to the point that I seriously wished I were dead. I am not exaggerating in the slightest. Sometimes I’d get really dizzy and hear an intense buzzing in my ears right before I almost passed out. The pain was unbearable; I often had to miss school and work because of my period. I recently underwent surgery and was recommended Lupron. I read horrible reviews about it for weeks leading up to my doctor appointment and was terrified to try it, but so far I haven’t had any problems other than hot flashes (and that’s MUCH preferable to the agonizing pain I used to be in). Of course, it’s only been a few months since I got the injection, so we’ll see...but so far it’s been great! Don’t let the reviews scare you; if you’re in good health like I am, you probably won’t experience serious complications or side effects. Hope this helps!"

• Amb...
• November 2, 2015

For Endometriosis "I have been taking this for 6 months now, about to start my 7th, and I love it! I will say the first month or so, I was really wondering what I had gotten myself into. But now, I am so glad I did it. I take the 1-a-month, not the 3-month shot. I haven't had a period in 5 months, and I haven't cramped in 5 months. I was having hot flashes before I started taking this, and I will say that at times they are way worse, but I would much rather deal with hot flashes than be huddled over in my bed because the cramps are so bad that I can't even function. I do understand that some people have bad experiences with things, and some people don't. It is all up to your body. Everyone's body is different. I hope seeing a good review like this will help."

• Jen...
• Taken for 1 to 6 months
• February 13, 2020

For Endometriosis "I feel like I’m one of the few people who has had a positive experience on the medicine Lupron. I’ve been pain-free from my endometriosis for 3 months, now on my third dose. After my first dose, I had some joint pain and severe hot flashes for a couple of weeks, but those symptoms lessened as time went on. My mood has changed for the better while on this medicine, I no longer have pain from the endometriosis, and my only symptom from this medicine is minor hot flashes! I can’t believe it. This medicine has been a blessing."

• I...
• August 19, 2016

For Uterine Fibroids "I have been on Lupron for 3 years. I began the shot in 2013 with an 11 cm fibroid that was too large for surgery at the time. I am now in my late 50s and still testing positive on hormone tests. In other words, if I go off Lupron, I am assuming the fibroid will grow again and I will begin to menstruate again and have heavy bleeding and large clots. My headaches became much less, and I only have hot flashes towards the end of my 3-month shot. I get shots quarterly. My bone density was just shy of normal with no concerns for many years. I take calcium, D3, and K2 (MK7 - helps make calcium go to bone, not soft tissue like calcification and bone spurs). For me, it has been the best thing in my life. I can't imagine why people have bad results. Oh, and no weight gain."

• Mar...
• Taken for 1 to 2 years
• October 28, 2019

For Prostate Cancer "On Lupron beginning July 2017. Now 2019 and still on a 3-month dose. I experience all the known side effects, and it is not much fun. I am 66 years old and have advanced prostate cancer stage 3. My PSA is undetectable since surgery and 40 radiation treatments. Hot flashes, weight gain, fatigue, tingle in feet, itching, impotence, and bone aches. PSA is still undetectable...going off Lupron in May 2020...we will see what happens then."

• Anonymous
• Taken for 1 to 6 months
• August 26, 2019

For Uterine Fibroids "I got my first Lupron shot on 07/22/2019 for fibroids. My obgyn decided to put me on Lupron to attempt to shrink my fibroids/Uterus so I can have a safe hysterectomy. I haven't had a menstrual cycle since 07/22/2019, that's awesome. So far I am experiencing: the first week my buttock was very sore/tender from the injection site. I am experiencing a lot of hot flashes throughout the day and at night, they last a few minutes. No night sweats. My body, but mainly my legs, ache and feel tingly/numb. Restless nights, having trouble staying asleep. My hair is now very dry and brittle and hair loss (it was healthy before). Vaginal dryness. Memory problems, trouble focusing. I am forgetting a lot of things. Major mood swings, from very angry to crying. Increased appetite (carb craving). I hope all this is worth it in the end. None of these side effects are unbearable, but I definitely do not feel like myself. Round 2 coming up on 10/22/2019."

• ama...
• Taken for 1 to 6 months
• November 19, 2012

For Endometriosis "I started Lupron about a month ago. I started taking it after the doctor told me I had stage 1 endometriosis. About a year before, I found out I had PCOS, which caused me to gain a lot of weight, about 23 lbs. Since I've been on Lupron, I've been feeling so much better, and I've lost 7 lbs! The only thing I have been struggling with is the hot flashes. Other than that, I've been doing very well on the shot."

• LJo...
• December 15, 2014

For Endometriosis "I was diagnosed with Stage 4 endometriosis and was prescribed Lupron. After reading all of the horrible reviews and side effects, I was terrified to try this. After chatting with my doctor, we both agreed that this would be the most aggressive treatment as my husband and I would like to get pregnant one day. I am on month 3 of the shot, and I have to say that I am pleased. The worst thing are the hot flashes. For me, they are at least 10 times a day! But I will take that over the excessive cramping and pain any day. I feel minor cramps occasionally during the time I would normally have my period. I have experienced no depression, weight gain, weight loss, bleeding, joint pain, etc. I am hoping after the treatments I will be able to conceive."

• Ann...
• Taken for 6 months to 1 year
• May 31, 2015

For Uterine Fibroids "I had extremely painful periods and constant bleeding. My doctor started me on the shot in Jan. and had the second one in March. Best thing I ever did. No bleeding after the 1st month and no pain after the 2nd month. Side effects were, in my opinion, mild. Worst were the hot flashes, but in my opinion, worth it. Doctor only wanted me to have 2 shots, so after June, going to see what happens. I don't want to get on any birth control, so will see what happens. I'm really hoping this makes it all better."

• nel...
• June 19, 2017

For Uterine Fibroids "I had my heavy period and strong and constant pain, which stops me from doing my normal life for more than 5 years. Since I have started to inject this Lupron, it has changed my life. After all those painful years, now I have had 4 injections already and go for the fifth one. The only side effect I had is hot flashes, especially during nights, and some bone pain, which are nothing to compare with the pain I had for more than 5 years. It is really worth trying if you are experiencing heavy bleeding and pain."

• End...
• Taken for 1 to 6 months
• September 24, 2014

For Endometriosis "Stage 4 endometriosis. I've been on Lupron for 3 months and will get another injection next week. I've had a few hot flashes, about 1x/day occasionally, but not every day. I have stayed below my original weight by about 5 lb. Some moodiness/occasional depression. But overall, I haven't had any major problems! I was very worried about side effects before starting Lupron, but am glad I did it. I want to be healthy! I'm getting married next weekend also, so have been planning a wedding at the same time. We're hoping to get pregnant next year!"

• And...
• November 22, 2017

For Uterine Fibroids "I was diagnosed with a 13 cm fibroid. The doctor wanted to shrink it to be able to perform a laparoscopic hysterectomy. I was having constant heavy bleeding for months on end, even the tranexamic acid wasn't slowing it down. The first drug we tried was Fibristal. It was supposed to slow the bleeding and shrink the fibroid. I took this for 6 months, and it did absolutely nothing. The doctor then suggested Lupron Depot. The first week on Lupron was hard. Bleeding was much heavier than before (which was already horrible). But by week 2, the bleeding completely stopped. By 5 months on Lupron, my fibroid had shrunk to 11 cm. A bit of hot flashes, some fogginess/irritability, but that's normal for me...lol."

• MoM...
• Taken for 1 to 6 months
• May 6, 2020

For Endometriosis "I was put on Lupron Depot for three months for endometriosis. I received an injection every month. My treatment started in January and ended the first Saturday in March 2020. The side effects weren't all that bad. I got my period on my dose, but it eventually went after that. I had, however, severe headaches that made me dizzy, experienced some mood changes (mostly anger), painless sex, hot flashes (manageable), and joint pains at the end of my last shot. The joint pains are mostly in my knees and fingers, but I only experience those after waking from a nap. Once I get up and start moving about, they disappear. I now await my cycle to return. It has been eight weeks since my last injection, and signs of my period returning are back. I'm spotting and experiencing mild cramps. All in all, my experience wasn't bad. Hope this helped someone. Oxoxox"

• Woo...
• Taken for 6 months to 1 year
• April 9, 2020

For Prostate Cancer "I’m a 66-year-old male who was diagnosed with moderately aggressive prostate cancer with a Gleason score of 8 and PSA of 7.2. I’ve had 2 Lupron injections, which have caused the following side effects: a chemical smell, muscle weakness, hot flashes, fatigue, PSA -"

• Not...
• Taken for 1 to 6 months
• January 22, 2015

For Endometriosis "I am 37, and for the most part, have been very healthy... never pregnant and married for three years. I have had an ovarian cyst, but have been controllable. On Nov. 9, 2014, I went to the ER, and the next day I was having a mass and 6' of my colon removed due to endometriosis. I had stage 4. My OBGYN suggested this shot. I read all the reviews and was VERY leery of starting it, but I just took my second shot. It has not been so bad. I have experienced hot flashes and weight gain. I have about 4-6 hot flashes a night, but no sweats yet. I am hungry ALL the time, and it seems the more I eat, the more I want. I can't seem to get full. I have gained 10 pounds in about 6 weeks. My mood has been good, though. I have had to start Osphena due to side effects."

• Kri...
• February 18, 2020

For Endometriosis "Ok y’all, I admit before taking Lupron Depot 11.25 mg, 3-month injection; I read every review I could find. I was disappointed to find mainly negative reviews, but I took a leap of faith and decided to get the injection anyway. Within the first month, I truly regret that decision. In tough situations, I typically look for the silver lining. However, I was not prepared for the extreme fatigue (no more 5 a.m. workouts), hot flashes all day, every day, night sweats that literally leave my side of the bed soaked (it’s totally gross), but the topper is body aching and hurting down to my muscles and bones like I have the flu... every day going on 63 days straight. I am 38 years old, in good shape, active when I started the injection. I was 115 lbs; I am now 130 lbs with no energy. Needless to say, I am declining the second treatment and look forward to 2-6 months when all of the side effects should fully wear off and hopefully get my normal life back."

• See...
• Taken for 1 to 6 months
• June 27, 2016

For Endometriosis "I would like to address women who already struggle with depression, insomnia, or mood disorders, like myself. If you're already bad off, don't do this to yourself, it might be the final 'push.' I got the 3-month shot (+add-back), and it made me suicidal. My moods went from extreme anger to sobbing, insomnia, hot flashes, and my left arm kept going numb in daily activities! This went on for a month, at 2 months, I leveled out. Not far into the 3rd month, the hot flashes came back, cold sweats (felt like drug withdrawal), and my pain was back! I went to my OB/GYN 1 week early because of this to find I had grown 11 new painful cysts! It didn't even work, and to stop it is also unpleasant (withdrawals). Worst med decision I ever made! HELL!"

• Ton...
• Taken for 1 to 2 years
• July 24, 2020

For Prostate Cancer "Taking Lupron injections for 7 months, out scheduled 18 months for prostate cancer. Experiencing common side effects like hot flashes, weight gain, reduction in size of testicles. Completed 28 treatments of radiation this past May. Taking injections in the buttocks every 3 months. Injections are not bad. A little soreness for a couple of days. The side effects are manageable so far."

• use...
• February 1, 2012

For Endometriosis "I was actually on Lupron Depot for 18 months. My periods stopped within a week, and my pain was gone within the first month. I almost didn't go on it because of the horror stories I read online, but I'm glad I did. My skin broke out more than normal, but nothing a little makeup couldn't hide. The hot flashes were intense at first, but slowly started to subside. After six months, they completely stopped. I also fully understand night sweats. The side effects were well worth it to me since I no longer have cramps that hurt so badly I pass out. I am also enjoying being period-free after never having a regular cycle and being anemic the better part of my life."