Lupron Depot and Night Sweats: What Users Say

• 1Sw...
• Taken for less than 1 month
• January 29, 2014

For Endometriosis "I was on Lupron for 6 months back in 09. The side effects weren't bad for me at first, but I have to say the night sweats were the worst! I just hated waking up in the middle of the night, needing to shower because I was so sweaty. However, I was pain-free! I had an AWESOME summer and went camping, mountain biking, traveling. My pain has slowly come back over the years, and my (new) doctor just gave me my first shot of Lupron yesterday. I am hoping it works just as well as it did the first time. I want to be me again."

• Kri...
• February 18, 2020

For Endometriosis "Ok y’all, I admit before taking Lupron Depot 11.25 mg, 3-month injection; I read every review I could find. I was disappointed to find mainly negative reviews, but I took a leap of faith and decided to get the injection anyway. Within the first month, I truly regret that decision. In tough situations, I typically look for the silver lining. However, I was not prepared for the extreme fatigue (no more 5 a.m. workouts), hot flashes all day, every day, night sweats that literally leave my side of the bed soaked (it’s totally gross), but the topper is body aching and hurting down to my muscles and bones like I have the flu... every day going on 63 days straight. I am 38 years old, in good shape, active when I started the injection. I was 115 lbs; I am now 130 lbs with no energy. Needless to say, I am declining the second treatment and look forward to 2-6 months when all of the side effects should fully wear off and hopefully get my normal life back."

• use...
• February 1, 2012

For Endometriosis "I was actually on Lupron Depot for 18 months. My periods stopped within a week, and my pain was gone within the first month. I almost didn't go on it because of the horror stories I read online, but I'm glad I did. My skin broke out more than normal, but nothing a little makeup couldn't hide. The hot flashes were intense at first, but slowly started to subside. After six months, they completely stopped. I also fully understand night sweats. The side effects were well worth it to me since I no longer have cramps that hurt so badly I pass out. I am also enjoying being period-free after never having a regular cycle and being anemic the better part of my life."

• alp...
• Taken for 6 months to 1 year
• August 21, 2018

For Uterine Fibroids "I am 28 with a 21 cm x 13 cm uterine fibroid. I was told my surgery would be risky and would leave me with a scar from under my chest to my pelvic area. Since I am only 28 and would like to have children of my own, they decided to put me on Lupron for 6 months to shrink the fibroid by hopefully 50% and have a much smaller and less risky surgery. Went on the shot in June, with the first month being the hardest, with headaches, night sweats, hot flashes, and my first period being very heavy with lots of clots. But I am on my second shot, 2.5 months in, and I can say most of those symptoms went away. I only get hot flashes, which are definitely bearable."

• cmf...
• Taken for 1 to 6 months
• August 19, 2015

For Uterine Fibroids "I had the 3-month 11.25 mg on 3/30/2015 to shrink my giant fibroid to the size that the laparoscopic myomectomy can be performed. I had no symptom of side effects for the first month and also had my period, but ever since the second month (May), the side effects have been really hitting me hard; including hot flashes and night sweats. I had my surgery at the end of June, and my doctor confirmed that I had reacted to the Lupron more than expected, as the fibroid not only shrank but part of it was degenerated. So, instead of a 2-hour operation, it ended up being a 6-hour one. Now, it's been 5 months, and the Lupron is still lasting (period still not back yet); don't know when it will be gone..."

• Anonymous
• Taken for 1 to 6 months
• April 24, 2015

For Endometriosis "I was diagnosed with Stage 4 endometriosis and had major surgery. I was only able to take four of the six shots. The side effects are terrible. I had almost all of them. I took my last shot in March 2015. It has been one month, and I am now experiencing panic and anxiety attacks along with high blood pressure. I am only 37 and gained weight, now weighing 155, and have a blood pressure of 142/103. I have never had high blood pressure until the third month of the shot. I have hot flashes, night sweats, chest pains that sent me to the ER, vaginal discharge, painful intercourse, vomiting the day I got the shot. It has been an awful experience. I am praying that when it gets all out of my system, I will not see any of these side effects anymore."

• Ano...
• Taken for less than 1 month
• May 4, 2016

For Uterine Fibroids "Received a 3-month shot two weeks ago to stop heavy menstrual bleeding in preparation for a hysterectomy next month. My period started, and the bleeding is just as extreme as usual. No relief in blood or pain with this drug. Have experienced hot flashes (minor), headaches (minor), night sweats, nausea (moderate), and have pain in the upper right back area. Will be seeing the doctor later this week to get checked on. I know it's early in the process, but I'm disappointed. I took it knowing about the side effects, but was willing to go along with them to get my bleeding under control and to build up my iron stores."

• Me2...
• August 31, 2018

For Endometriosis "Took the 3-month Lupron Depot shot just one time. It's now 3 months since I had the shot. My reasons for taking this poison are due to extreme PMDD condition, which I also have endo, but the PMDD outweighs! So all my symptoms since the very first week of the injection have been severe hot flashes, night sweats, more fatigue, whole body aches. Just in the last month, my hair has been falling out! Very dry, thin now - I'm extremely moodier than before. This was the worst thing I've done, and I'm super mad at all these doctors who really have no clue what they're doing to people. We are all their guinea pigs. I went 4 days ago to the doctor, and he put me on Primaire (hormone replacement). I'm waiting in misery to see if this added med helps. So far, the new med has had me in tears every day for no reason, a massive migraine, and overall losing my mind! Never ever take Lupron! Just do an internet search on Lupron victims."

• Dan...
• Taken for 1 to 6 months
• April 27, 2012

For Endometriosis "2/9/12 I had a full hysterectomy (uterus and cervix removed) due to fibroids. My doctor found endometriosis everywhere. My doctor put me on Lupron about a month after the surgery and I had my second shot on 4/20/12. I got hot flashes right after the first shot, but they are really not that bad. Night sweats are more uncomfortable and my joints and muscles are achy and stiff. However, my mood is pretty terrible. I have no patience for anything and feel pretty grumpy most of the time. My pain is lessening but still present. That said, if I can be rid of most of the pain after the 6-month regimen, it will have been worth it!"

• Anonymous
• March 6, 2010

For Endometriosis "At first, I really thought the Lupron treatments were worth it, but now that I have made a trip to the Emergency Room. Well, let's just say if you are going to go the route of Lupron, you better be single. This drug takes its toll on the family, not just you. Everyone goes through the mood swings, headaches, blood pressure scares, joint pain, feeling like you are going to pass out. So, no taking your kids to school or sporting events. No joining carpools. Don't get too far away from the restroom, urinating more often is not unusual. The things that are the easiest to handle are the hot flashes, night sweats, and chills."

• Lal...
• November 5, 2018

For Endometriosis "I will say I virtually have no periods and have had maybe 3 endo pain days that don’t come close to what the pain used to be. NOW the side effects are horrid! BUT I’ll take the side effects over the pain in periods. My bones ache, not unbearable, but uncomfortable. The night sweats, bad but bearable. I’m tired lots, but I can function with some caffeinated tea & B12 for energy. Mood swings and little depression/anxiety. It’s not intense depression for me, like nothing that makes me want to harm myself, it’s just more of a dark cloud following you around. So if you have mental “instability” before taking the drugs, make sure you talk to your doctor. I did not lose hair, and my hair did NOT thin/fall out. I did not gain weight. The side effects still make the medicine worth taking because I have no pain or real periods. I get the shot every 3 months (I’m on 9 months) and take a pill that comes in the shot package. The pill is taken daily, shot is every 3 months for me. Good luck!"

• Ste...
• December 21, 2019

For Endometriosis "I have stage 4 endometriosis and adenomyosis. Had emergency surgery 3 years ago due to a large endometrioma causing a total blockage of my sigmoid colon. Everyone's reports on here about unbearable pain and severe bleeding-yup, same for me. I've been bleeding nonstop for over a year now. Received my first 1-month dose of Lupron on 11/22/19. The only side effect was a slight uptick in libido the first two weeks during the initial estrogen spike. The last week of the month, I got my period, but the bleeding and pain were much reduced from before. Noticed an improvement in pain during intercourse. I am on the add-back and have had no night sweats, hot flashes, or vaginal dryness. No impact on my mood that I could notice. Received my second dose, the 3-month long dose, yesterday (12/20/19). Can't comment yet on the experience, but I'm sure hoping to stop bleeding entirely and eliminate the pain."

• cra...
• June 10, 2015

For Endometriosis "I am very happy I went on Lupron Depot. I am on my 6th month of it, and although the symptoms of hot flashes, night sweats, moodiness, and some weight gain are not fun, it still is VERY worth it. I have been pain-free (when I was in debilitating pain before) and no period, which is nice. Hopefully, I'll be able to get pregnant soon too!"

• Anonymous
• March 18, 2010

For Endometriosis "I just had my 5th shot yesterday. The past few months have been painless in regard to side effects other than night sweats and mood swings. I have not gained any weight, and everything seems pretty normal. Once again, other than the mood swings. These are harsh, and sometimes I feel like another person has taken over my body and thoughts."

• ska...
• Taken for 1 to 6 months
• November 8, 2016

For Endometriosis "I got a month shot right when I was about to start my period. Period ended up lasting about 12 days. I was told night sweats and menopausal symptoms would happen, but I did NOT expect the suicidal urges (I've been diagnosed with depression, but it was manageable before this shot), migraines - the worst migraines I've ever experienced in my life, nausea, cankles. I've had to take roughly 5 days off work just in the last 3 weeks, and I may even lose my job. I am so irritable and cannot sleep for the life of me. I wake up at least 30 times a night. I'd rather have my excruciating menstrual cramps than go through this ever again. My body did NOT like this AT ALL!"

• Ash...
• January 4, 2020

For Endometriosis "I have severe endometriosis and adenomyosis and am scheduled for a hysterectomy on Jan 29th. My doctor wanted me to get a couple of Lupron injections so that I can have some pain relief as well as experience some of the symptoms I will be dealing with after my surgery. Well, it's been 3 weeks since my first (and LAST) injection. I have night sweats every night as well as a full aching headache all day long. The headache goes away with Tylenol or sleep but is back the very next day. So I'm hoping the headaches stop once this horrible drug is out of my system. Didn't have headaches until I got this injection!!"

• Anonymous
• April 7, 2012

For Endometriosis "Had my first shot about a week ago. I have major pain in my joints (elbows and knees), hot flashes, and night sweats. But honestly, so far, so good. I am no longer feeling the horrible endometriosis pain. Will update more once I'm further in. Plan as of now is to do 6 months of Lupron and see if my fallopian tubes have less swelling and inflammation, as my husband and I would love a baby of our own. Good luck to all. This is not easy. But I am hoping it will be worth it."

• Jay...
• Taken for 1 to 6 months
• June 28, 2020

For Endometriosis "I was put on this medication after laparoscopic surgery to remove cysts that were causing me pain. They found out I have stage 2 endo and recommended the Lupron with the acetate pill. The first month was fine, but the second month my period came early and never stopped. I can deal with the hot flashes, but I've currently been bleeding and cramping for 4 weeks, and they just keep telling me to wait it out. I'm due for the second shot in July, and I don't know if it's going to help at all. I am depressed, and the night sweats are a lot to deal with. I would rather have dealt with the endo pain 2 days a month than to have done this."

• KBa...
• Taken for 1 to 2 years
• February 3, 2020

For Endometriosis "I had a very similar experience to Lora C. I was a mess on Lupron and very much not myself. I couldn't control my emotions, I was either dead inside or crying, there was no in-between. My night sweats were awful, and I was mean all the time. The worst part was probably my memory. I had no recollection of anyone's name, I could recognize their face and the fact that I definitely knew them, but never their names if I had met them after I was on Lupron. The shot also hurts like anything, and hot flashes are real. I was consistently warm all the time. Summer was unbearable. Also, the first few months were the worst endo pain I had ever felt. It was terrible. It finally went away after about month 4 or 5, and I was in a normal range of just feeling pressure down there. It wasn't nearly as painful, but always present."

• Mar...
• Taken for 1 to 6 months
• September 28, 2024

For Uterine Fibroids "I have been on Lupron for 4 months, about to have my fifth shot. I have a 10 cm submucosal fibroid which was causing pain, severe bleeding, and anemia. Since starting the Lupron, my migraines increased by double (I had to switch meds so I could go to work). I’ve gained 10 pounds, I have night sweats, hot flashes during the day, my mood gets angry and sad the week after the shot, and now my hair is thinning. I also am still bleeding daily (spotting). I was put on progesterone to offset some of the side effects. I have two more shots until my second surgery, and I can’t wait to be off this medication."

• Anonymous
• April 26, 2012

For Endometriosis "Got first shot Jan 2012. Side effects: night sweats, hot flashes, headache, and muscle ache all bearable, but hot flashes have interfered with sleep. Just got 2nd shot this week, 4-24-12. Have sore throat and headache, seem to be more agitated and irritable. Hot flashes are a bit worse, and headaches are coming back. Overall, if this is the gist of side effects, all worth it to make sure cancer, if spread, does not come back. Had hysterectomy Nov 2011 and found cancer in uterus. Doctors said it was contained to uterus, but for safety precautions, put me on Lupron."

• Tee...
• December 17, 2020

For Endometriosis "I have stage 4 endo with adenomyosis and large fibroids. I’m currently awaiting my 3rd dose of the Lupron injection. It hasn’t been a bad experience; just body aches, bad hot flashes, and night sweats. No real weight gain, actually lost 6 pounds since I started the injection. After my first injection, I had a minor period, and for my second injection, no period or pain. Coming into the 3rd injection being due, I’m starting to experience endo pain. Think I’m only going to do one round of Lupron."

• Nat...
• Taken for 1 to 6 months
• July 7, 2022

For Uterine Fibroids "I have had many years of heavy, painful periods. Diagnosed with a bulky uterus (size 16 weeks) with endometriosis and fibroids. My gynecologist recommended Lupron Depot to shrink my uterus before going for laparoscopic hysterectomy. I'm 53 years old. I have had 2 shots now and am going for my 3rd next week. I have had a lot of side effects from this medication: night sweats (not every night, mild), insomnia, no energy, restless legs/muscle spasms, depression (cry every day at least once), and mood swings (my poor family). So next week when I get shot #3, I am hoping that he will have my surgical date booked as I cannot live with the pain and constant bleeding. The shot plus add-back therapy has only given me hope that I will eventually get back to normal and a better quality of life."

• Ger...
• Taken for 5 to 10 years
• May 22, 2025

For Prostate Cancer "Lupron Depot 22.5. This is the second time in 9 years I have taken this shot. A recent finding of lymph node cancer was noted, so 5 radiation sessions were to be administered. Two times while on the table to begin this radiation, the radiologist could not locate cancer that was present on a PET scan. It seems the Lupron masked the cancer. That is where I am now. Both times on Lupron I had night and day sweats, muscle aches, and a general feeling of weakness. I had a prostatectomy in 2016. I also had renal cancer in both kidneys. One was cryoablated (right) and the other was by partial nephrectomy (1/25). The uro said the renal cancers did not come via prostate."

• Bad...
• Taken for less than 1 month
• February 17, 2022

For Endometriosis "Almost as soon as the injection of Lupron Depot 3.75 was administered, I experienced the most horrible night sweats hourly, making sleep impossible, burning palms of hands, raised pulse, and headaches. Two weeks after the injection, I experienced pain in knees, difficulty in crouching, walking up and down stairs, increased pain in joints, hands, and feet."