Comparing Depo-Provera vs Orilissa
| Depo-Provera | Orilissa |
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| Depo-Provera (medroxyprogesterone) | Orilissa (elagolix) |
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Prescription only
Prescribed for Birth Control. Depo-Provera may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Endometriosis. Orilissa may also be used for purposes not listed in this medication guide. |
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| More about Depo-Provera (medroxyprogesterone) | More about Orilissa (elagolix) | ||||||||||||||||
| Generic Status | |||||||||||||||||
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No lower-cost generic available |
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| Ratings & Reviews | |||||||||||||||||
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Depo-Provera has an average rating of 4.2 out of 10 from a total of 1949 ratings on Drugs.com. 28% of reviewers reported a positive effect, while 55% reported a negative effect. |
Orilissa has an average rating of 5.2 out of 10 from a total of 108 ratings on Drugs.com. 38% of reviewers reported a positive effect, while 40% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
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See also: Depo-Provera side effects in more detail. |
See also: Orilissa side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Depo-Provera prices and generic prices |
View all Orilissa prices |
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| Dosage Form(s) Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other medroxyprogesterone brands include: depo-subQ provera 104, Provera |
N/A |
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| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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401 hours |
6 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 219 drugs are known to interact with Depo-Provera:
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A total of 335 drugs are known to interact with Orilissa:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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September 23, 1960 |
July 23, 2018 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
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N/A |
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| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.