Comparing Naltrexone vs Sertraline

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Naltrexone	Sertraline	Enter another drug to compare

Naltrexone

Sertraline

Prescription only

Naltrexone is used as an adjunct to social and psychotherapy in the treatment of opioid and alcohol addiction. People taking naltrexone need to have completely stopped taking all types of opioids... View more

Prescription only

Sertraline is an effective antidepressant with less potential for drowsiness than other antidepressants. Headaches, nausea, diarrhea, weight loss, insomnia, tremors, and sexual dysfunction are the... View more

More about Naltrexone

More about Sertraline

Ratings & Reviews

Naltrexone has an average rating of 7.9 out of 10 from a total of 602 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 16% reported a negative effect.

Sertraline has an average rating of 7.3 out of 10 from a total of 4567 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 18% reported a negative effect.

View all 602 reviews

View all 4567 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Nausea (8.1%)
Anxiety (7.1%)
Tiredness (6.5%)
Depression (6.0%)
Insomnia (5.6%)
Fatigue (5.0%)
Headaches (4.8%)

View all Naltrexone side effects

Anxiety (17.9%)
Nausea (12.2%)
Insomnia (10.7%)
Headaches (7.7%)
Tiredness (7.2%)
Sexual dysfunction (6.9%)
Depression (6.7%)

View all Sertraline side effects

Drug Class

Selective serotonin reuptake inhibitors

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	20 each
Strength	50 mg
Per unit^*	$1.75
Cost^*	$34.97

View all Naltrexone prices

Quantity	50 each
Strength	100 mg
Per unit^*	$0.58
Cost^*	$28.98

View all Sertraline prices

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Dosage Forms

Oral tablet

Oral capsule
Oral concentrate
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

10 hours

66 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 352 drugs are known to interact with Naltrexone:

34 major drug interactions (160 brand and generic names)
318 moderate drug interactions (1321 brand and generic names)

A total of 673 drugs are known to interact with Sertraline:

157 major drug interactions (613 brand and generic names)
511 moderate drug interactions (2147 brand and generic names)
5 minor drug interactions (25 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Naltrexone may cause liver problems, and using it with other medications that can also affect the... View more

Using sertraline together with alcohol may increase side effects such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

November 20, 1984

December 30, 1991

WADA Class View classifications

N/A

More Information

Patient Resources

Naltrexone uses

Sertraline uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Naltrexone vs Sertraline

See also:

Suboxone

Subutex

Ozempic

Belbuca

Vivitrol

Sublocade

Butrans

Campral

Brixadi

Zubsolv

Further information

Comparing Naltrexone vs Sertraline

See also:

Further information

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