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Naltrexone Dosage

Medically reviewed by Drugs.com. Last updated on Aug 14, 2023.

Applies to the following strengths: 50 mg; 380 mg; 1.5 mg; 4.5 mg

Usual Adult Dose for Alcohol Dependence

Oral:
Average dose: 50 mg orally once a day
Duration of therapy: 12 weeks

Intramuscular:
380 mg intramuscularly every 4 weeks/once a month

Comments:

Usual Adult Dose for Opiate Dependence

Oral:
Initial dose: 25 mg orally once a day
Maintenance dose: 50 mg orally once a day (if no withdrawals on 25 mg/day)

Intramuscular:
380 mg intramuscularly every 4 weeks/once a month

Comments:



Use(s): Blockade of the effects of exogenously administered opioids

Renal Dose Adjustments

No adjustment recommended for mild renal impairment
Use with caution.

Liver Dose Adjustments

No adjustment recommended for mild to moderate hepatic impairment

Dose Adjustments

Alternative Dosing Schedules for Supervised Administration:
50 mg every weekday with 100 mg on Saturday
100 mg every other day
150 mg every third day



Naloxone Challenge Test:

Intravenous: Inject 0.2 mg naloxone; observe for 30 seconds for withdrawal signs/symptoms

Subcutaneous: Administer 0.8 mg naloxone; observe for 20 minutes for withdrawal signs/symptoms

Comments:

Precautions

The US FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for Vivitrol(R). It includes a REMS document to warn patients about severe injection site reaction associated with this drug. For additional information: www.accessdata.fda.gov/scripts/cder/rems/index.cfm

CONTRAINDICATIONS:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

General:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.